Table 2.
Studies contributing to the analysis of serum lipids and colorectal adenoma
| Author/reference and country | No. of cases/controls | Source of controls | Age (years) | Type of lesion | Serum lipid measurement, RR (95 % CI), start to end | Controlled variables |
|---|---|---|---|---|---|---|
| Case–control studies | ||||||
| Bird et al. (1996)( 20 ), USA | 486/520 | Hospital | 62 | 486 left colon and rectum adenomas | TC, 1·2 (0·8, 1·8) | Gender and age |
| TAG, 1·5 (1·0, 2·3) | ||||||
| HDL-C, 1·6 (0·9, 2·8) | ||||||
| Chung et al. (2006)( 22 ), Korea | 105/105 | Hospital | 58 | 105 colorectal adenomas | TAG, 1·2 (0·5, 2·9) | Age and gender |
| TC, 0·7 (0·3, 1·6) | ||||||
| Park et al. (2000)( 9 ), Korea | 134/134 | Hospital | Not reported | 134 male colorectal adenomas | TAG, 2·98 (1·2, 7·4) | Age and gender |
| TC, 2·44 (0·6, 10·0) | ||||||
| HDL-C, 2·23 (0·8, 6·2) | ||||||
| LDL-C, 1·31 (0·4, 4·3) | ||||||
| Hu et al. (2011)( 23 ), Taiwan | 397/2709 | Hospital | 52 | 379 colorectal adenomas | TAG, 1·18 (0·91, 1·53) | Non-polyp/cancer control |
| HDL-C, 0·94 (0·71, 1·24) | ||||||
| Kim et al. (2007)( 6 ), Korea | 731/1800 | Hospital | 54 | 731 colorectal adenomas | TAG, 1·16 (0·96, 1·40) | Non-polyp/cancer control |
| HDL-C, 1·07 (0·84, 1·36) | ||||||
| Morita et al. (2005)( 31 ), Japan | 756/1751 | Hospital | 49–57 | 756 male colorectal adenomas | TAG, 1·18 (0·98, 1·42) | Not reported |
| HDL-C, 0·85 (0·61, 1·18) | ||||||
| Otani et al. (2006)( 8 ), Japan | 782/738 | Hospital | 61 | 782 colorectal adenomas | TAG, 1·5 (1·1, 2·05) | Not reported |
| Tsilidis et al. (2010)( 39 ), USA | 132/260 | CLUE II cohort | 55 | 132 colorectal adenomas | TC, 0·97 (0·49, 1·92) | Age, gender, race, date of blood draw, fasting |
| HDL-C, 0·92 (0·45, 1·90) | ||||||
| TAG, 0·85, 0·40, 1·81 | ||||||
| Author/reference and country | Enrolment | Study population | Age (years) | Colonoscopy | Type of lesion | Serum lipid measurement, RR (95 % CI), start to end |
| Cross-sectional studies | ||||||
| Bayerdorffer et al. (1993)( 19 ), Germany | 1988–1989 | 822 consecutive patients | 52·45 | Yes | 194 colorectal adenomas | HDL-C, 0·61 (0·4, 0·9) |
| LDL-C, 1·91 (1·6, 2·3) | ||||||
| TC, 1·36 (0·8, 2·3) | ||||||
| Kono et al. (1990)( 28 ), Japan | 1986–1988 | 1297 men | 49–56 | Yes | 88 male colorectal adenomas | TC, 1·3 (0·7, 2·4) |
| HDL-C, 0·6 (0·3, 1·2) | ||||||
| TAG, 1·5 (0·8, 2·8) | ||||||
| Kono et al. (1993)( 29 ), Japan | 1988–1990 | 1363 men | 48–56 | Yes | 138 left-sided colon adenomas | TC, 0·8 (0·4, 1·6) |
| HDL-C, 1·1 (0·6, 2·0) | ||||||
| LDL-C, 0·8 (0·5, 1·3) | ||||||
| TAG, 0·8 (0·5, 1·3) | ||||||
| Tabuchi et al. (2006)( 36 ), Japan | 1995–2003 | 4887 patients | 10–94 | Yes | 3821 colorectal tubular adenomas | TC, 1·04 (1·0, 1·1) |
| TAG, 1·13 (1·0, 1·3) | ||||||
| Yang et al. (2013)( 10 ), Korea | 2006–2009 | 19 281 consecutive participants | 40–79 | Yes | 5958: 5504 non-advanced colorectal adenomas and 454 advanced colorectal adenomas | TC, 1·13 (0·9, 1·4) |
| HDL-C, 1·09 (1·0, 1·2) | ||||||
| LDL-C, 1·19 (1·1, 1·3) | ||||||
| TAG, 1·36 (1·2, 1·5) | ||||||
| Author/reference and country | Study population | Age (years) | Type of lesion | Serum lipid measurement, RR (95 % CI), start to end | Controlled variables | |
| Cohort studies | ||||||
| Ashbeck et al. (2009)( 18 ), USA | 392 individuals from Wheat Bran Fiber trial and the Ursodeoxycholic Acid trial | 66 | 770 non-advanced neoplasia | TAG, 0·97 (0·78, 1·21) | Age and study | |
| 333 advanced neoplasia | TAG, 0·87 (0·64, 1·18) | |||||
| TAG, 1·28 (0·92, 1·78) | ||||||
| TAG, 0·88 (0·56, 1·38) | ||||||
| HDL-C, 0·94 (0·74, 1·19) | ||||||
| HDL-C, 0·87 (0·63, 1·20) | ||||||
| HDL-C, 1·28 (0·89, 1·84) | ||||||
| HDL-C, 0·86 (0·52, 1·42) | ||||||
| Kim et al. (2012)( 27 ), Korea | 6438 Korean participants in the Colorectal Polyp Registry | Not reported | 1771 patients with colorectal adenomatous polyps | HDL-C, 1·13 (0·8, 1·6) | Age, education, occupation, household income, marital status | |
| TAG, 0·84 (0·6, 1·2) | ||||||
| Liu et al. (2010)( 30 ), China | 4872 general Chinese population | 50 | 719 colorectal adenoma | TAG, 1·26 (1·04, 1·53) | Age, gender, smoking, alcohol | |
| HDL-C, 1·30 (1·10, 1·54) | ||||||
| Kaneko et al. (2010)( 26 ), Japan | 727 Japanese population | Not reported | 727 colon tumours | TAG, 1·00 (0·99, 1·01) | Age, dietary intake | |
| TAG, 1·01 (1·00, 1·02) | ||||||
| LDL-C, 1·00 (0·98, 1·02) | ||||||
| LDL-C, 1·00 (0·99, 1·01) | ||||||
| HDL-C, 1·01 (1·00, 1·02) | ||||||
| HDL-C, 1·02 (1·00, 1·04) | ||||||
RR, risk ratio; TC, total cholesterol; HDL-C, HDL-cholesterol; LDL-C, LDL-cholesterol.