Table 3.
Pharmacokinetic analysis of KB on day 1
| Parameters | 0.06 mg/kg | 0.12 mg/kg | 0.24 mg/kg |
|---|---|---|---|
| AUC0–24h (h·ng/mL) | 283.64 (37.90) | 465.91 (188.43) | 1216.13 (97.78) |
| AUC0–8h (h·n/mL) | 271.55 (35.86) | 443.09 (174.02) | 1158.49 (87.91) |
| AUC_%Extrap (%) | 0.32 (0.09) | 0.50 (0.57) | 0.20 (0.07) |
| AUCinf (h·n/mL) | 284.23 (37.95) | 467.76 (188.31) | 1218.63 (98.33) |
| CL (L/h) | 10.16 (1.94) | 13.49 (4.47) | 9.35 (0.73) |
| Cmax (ng/mL) | 150.72 (17.40) | 269.97 (68.89) | 622.73 (46.93) |
| Kel (1/h) | 0.19 (0.04) | 0.17 (0.06) | 0.21 (0.03) |
| MRTinf (h) | 1.88 (0.11) | 1.86 (0.52) | 2.05 (0.15) |
| Tmax (h)# | 1.00 (1.00–1.00) | 1.00 (0.50–1.00) | 1.00 (1.00–1.00) |
| Vd (L) | 55.24 (17.39) | 101.90 (84.85) | 45.74 (6.40) |
| T1/2 (h) | 3.72 (0.78) | 4.88 (2.93) | 3.40 (0.50) |
Data was expressed in mean (standard deviation)
AUC0–24h area under the plasma concentration–time curve from zero time to 24 h, AUC0–8h area under the plasma concentration–time curve from zero time to 8 h, AUC_%Extrap extrapolated area percentage, AUCinf area under the plasma concentration–time curve from zero time to inferred infinite time, CL apparent clearance rate, Cmax peak plasma concentration, Kel elimination rate constant, MRTinf average retention time, Tmax time to peak plasma concentration, Vd apparent volume of distribution, T1/2 elimination half-life
#Data was expressed in median (range)