Table 2.

Key points in treating opioid-induced hypogonadism [40•, 50–54]

1	Degree of hypogonadism may depend on the opioid used. Buprenorphine, tapentadol and hydrocodone may cause less hypogonadism
2	Risk of hypogonadism is greater with increasing opioid doses
3	Risk of hypogonadism is greater with those taking long-acting over short-acting formulations of opioid
4	Degree of hypogonadism may be greater in those taking long-term opioids