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. 2023 May 16;40(7):3038–3055. doi: 10.1007/s12325-023-02525-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 3 — Long-term extrapolations of (A) RFS, (B) DMFS, and (C) OS, with validations against external studies. DMFS distant metastases-free survival, OS overall survival, RFS recurrence-free survival, USON US Oncology Network. With the exception of the real-world USON study, all of the external studies shown in the RFS and OS graphs separately reported these survival endpoints for stage IIB and IIC melanoma. Therefore, to allow for interpretable comparisons against modeled RFS and OS in the modeled target population, the stage IIB and IIC Kaplan-Meier curves from each study were pooled as a weighted average based on the percentage of patients with stage IIB melanoma in KEYNOTE-716 (i.e., 64.8%)