Fig. 3.

Use of enriched pathways to dissect a transcriptional program specific to the Cyp1b1-null mice mitigating the effects of hyperoxia exposure in WT mice. A. Heatmap with unbiased clustering of enriched pathways by Gene Set Enrichment Analysis (GSEA) from comparisons of hyperoxia response and potential mitigation of hyperoxia effects in mouse models Cyp1a1-, Cyp1a2-, Cyp1b1-null (KO). Number of positively and negatively enriched pathways are shown in bar graph. B. Hypothesized hyperoxia mitigation model in Cyp1b1-null mice. C. Venn diagram to identify candidate pathways to explain the mitigation of hyperoxia effects in Cyp1b1-null mice, where pathway enrichment is oppositely enriched. D. Pathways mitigated in the Cyp1b1-null mice but not in Cyp1a1-null or Cyp1a2-null mice. E. Top gene ontology enriched terms in the 49 hyperoxia-induced pathway candidates for hyperoxia effects mitigated in the Cyp1b1-null mice. F. Top gene ontology enriched terms in the 69 hyperoxia-suppressed pathway candidates for hyperoxia effects mitigated in the Cyp1b1-null mice.