Fig. 4.

Gene-level evaluation of hyperoxia exposure responses mitigated in Cyp1b1-null mice. A. Selected pathways enriched by hyperoxia in WT (grey bars) and mitigated in Cyp1b1-null mice (green bars). B. qRT-PCR to assess mRNA expression of genes involved in a typical hyperoxia response and found in the enriched pathway genesets. Fold change relative to WT normoxia (RA) for each treatment is shown, with asterisks indicating significance (*p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.0001). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)