Table 1:
Clinical and demographic characteristics of European and African ancestry ADRD cases and controls
| European Ancestry |
African Ancestry |
|||||
|---|---|---|---|---|---|---|
| Controls (n=170,361) | Controls (n=170,361) | p-value | Controls (n=16,191) | Controls (n=1,443) | p-value | |
|
| ||||||
| Strict AD diagnosis | 0 (0) | 2,786 (25.07) | ---- | 0 (0) | 271 (18.78) | ---- |
|
| ||||||
| Age (mean/SD) | 77.77 (6.70) | 82.86 (7.57) | <2.2e-16 | 76.07 (5.91) | 80.70(7.76) | <2.2e-16 |
| Male | 166,274 (97.60) | 10,837 (97.53) | 0.43 | 15,604 (96.37) | 1,404 (97.51) | 0.034 |
| Lifetime PTSD diagnosis | 15,089 (8.86) | 1,175 (10.57) | <2.2e-16 | 3,028 (18.70) | 258 (17.88) | 0.62 |
| PTSD Onset Age (mean/SD) | 54.99 (14.23) | 53.15 (18.17) | 0.0024 | 53.49 (14.65) | 52.62(17.09) | 0.52 |
| History of TBI | 12,446 (7.31) | 1,294 (11.65) | <2.2e-16 | 692 (4.27) | 130 (9.01) | 5.041e-16 |
| Comorbid PTSD and TBI | 2,238 (1.31) | 250 (2.25) | <2.2e-16 | 221 (1.36) | 31 (2.15) | 0.0070 |
| Education (mean/SD) | 3.65 (1.57) | 3.40 (1.63) | <2.2e-16 | 3.29 (1.43) | 2.98(1.49) | 5.03e-14 |
| Smoking History | 126,914 (74.50) | 7,957 (71.61) | 0.00046 | 11,655 (71.98) | 977 (67.71) | 0.047 |
| Problematic Alcohol Use | 55,071 (32.33) | 2,263 (20.37) | <2.2e-16 | 3,739 (23.09) | 203 (14.07) | <2.2e-16 |
| APOE ε4 carrier | 39,138 (22.97) | 3,922 (35.30) | <2.2e-16 | 5,223 (32.26) | 601 (41.65) | <2.2e-16 |
Note: Numbers listed are counts (and percentages of cases or controls) unless noted otherwise. Age is based on the veteran’s age at last visit in the medical record from the MVP 19.2 phenotype release. Education was based on a 7-point scale.