Stage 1 (Outer Loop)
$\underset{w}{\mathit{\text{min}}}$	$f_{\mathit{\text{meta}}}\left(w\right)= \frac{{\sum }_i^m{2}^{-{\tau }_i+1}\cdot F_{{\tau }_i}}{{\sum }_i^m{2}^{-{\tau }_i+1}}$
s.t.	w ≽ 0
	1T w ≤ 1	(1)
Stage 1 (Inner Loop)
$\underset{x}{\mathit{\text{min}}}$	$w_{\mathit{\text{PTV}}}\sum _{s\in \mathit{\text{PTVs}}}\frac{1}{N_s}\sum _{i\in s}{\left(d_i-\widehat{d}\right)}^2+\sum _{s\in \mathit{\text{OARs}}}\frac{w_s}{N_s}\sum _{i\in s}\Theta \left(d_i-\widehat{d}\right){\left(d_i-\widehat{d}\right)}^2$
s.t.	x ≥ 0
	$\stackrel{\rightharpoonup }{\mathit{\text{d}}} = \mathit{D}\stackrel{\rightharpoonup }{\mathit{x}}$	(2)
Meta-scoring Tier List
	$F_{{\tau }_0} = \frac{1}{\left|\mathit{\text{PTVs}}\right|}\sum _{sϵ\left\{\mathit{\text{PTVs}}\right\}}\mathit{\text{min}}\left(1,\mathit{\text{ max}}\left(\frac{H{I}_s - H{I}_{s,(-)}}{H{I}_{s, (+)}- H{I}_{s,(-)}},0\right)\right)$
	$F_{{\tau }_1} = \mathit{\text{min}}\left(1,\mathit{\text{max}}\left(\frac{C{I}_{(+)}-CI}{C{I}_{(+)} -C{I}_{(-)}},0\right)\right)$
	$F_{{\tau }_2} = \frac{1}{\left|\mathit{\text{OARs}}\right|}\sum _{s\in \left\{\mathit{\text{OARs}}\right\}}\mathit{\text{min}}\left(1,\mathit{\text{max}}\left(\frac{{\overline{\text{d}}}_s -{\overline{\text{d}}}_{s,(-)}}{{\overline{d}}_{s,(+)}-{\overline{\text{d}}}_{s,(-)}},0\right)\right)$
	$F_{{\tau }_3} = \frac{1}{\left|\mathit{\text{OARs}}\right|}\sum _{s\in \left\{\mathit{\text{OARs}}\right\}}\mathit{\text{min}}\left(1,\mathit{\text{max}}\left(\frac{{\overline{\text{d}}}_s -{\overline{\text{d}}}_{s,(-)}}{{\overline{d}}_{s,(+)}-{\overline{\text{d}}}_{s,(-)}},0\right)\right)$
		(3)