Table 4.
Quantitative comparison is performed for head and neck cases, where we assess target coverage, dose homogeneity, conformity, and OAR sparing. Methods are compared using the Wilcoxon signed-rank test (p < 0.05) with the best values bolded for readability.
| PTV 52 | PTV 56 | PTV 70 | OAR | Mean Dose (μ) | D(2%) (Gy) | D(20%) (Gy) | D(40%) (Gy) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D 95 | HI | D 95 | HI | D 95 | HI | CI | ||||||
| Manual VMAT (~360 CPs) | 52.5 (0.5) | 7.40 (3.27) | 57.6 (0.6) | 3.42 (1.15) | 70.0 (0.0) | 5.22 (0.57) | 0.83 (0.02) | Cord | 15.7 (6.5) | 33.8 (4.6) | 29.7 (5.2) | 22.1 (11.4) |
| Brainstem | 12.0 (2.7) | 32.3 (4.3) | 22.2 (6.9) | 12.0 (5.2) | ||||||||
| Parotid R | 28.6 (6.1) | 55.8 (6.9) | 42.3 (6.0) | 31.3 (7.0) | ||||||||
| Parotid L | 26.2 (5.7) | 58.8 (6.4) | 40.7 (5.0) | 27.0 (8.3) | ||||||||
| Oral Cavity | 29.2 (3.2) | 55.9 (3.7) | 39.0 (4.0) | 30.0 (3.9) | ||||||||
| Larynx | 32.0 (4.6) | 57.2 (5.8) | 41.9 (5.8) | 32.5 (4.9) | ||||||||
| Body | 5.7 (0.7) | 45.5 (2.5) | 7.4 (2.0) | 1.1 (0.3) | ||||||||
| MP VMAT (~120 CPs) | 52.4 (0.5) | 6.03 (1.46) | 57.5 (0.6) | 2.66 (2.43) | 70.0 (0.0) | 4.34 (0.72) | 0.82 (0.05) | Cord | 14.1 (4.6) | 35.8 (4.2) | 27.9 (4.0) | 16.1 (7.2) |
| Brainstem | 11.1 (4.0) | 28.4 (2.5) | 20.6 (7.3) | 10.0 (7.2) | ||||||||
| Parotid R | 22.9 (4.3) | 52.4 (4.8) | 34.8 (5.2) | 21.3 (4.2) | ||||||||
| Parotid L | 24.1 (2.4) | 56.9 (6.5) | 34.5 (4.4) | 23.1 (2.9) | ||||||||
| Oral Cavity | 27.1 (2.5) | 55.7 (3.9) | 37.5 (4.1) | 24.5 (3.7) | ||||||||
| Larynx | 34.3 (5.1) | 54.3 (6.7) | 41.7 (5.3) | 26.7 (4.4) | ||||||||
| Body | 5.0 (0.5) | 44.3 (2.9) | 6.5 (1.9) | 0.2 (0.1) | ||||||||
| MP Boosted VMAT (~90 CPs) | 52.4 (0.5) | 5.85 (1.22) | 57.5 (0.6) | 2.68 (2.37) | 70.0 (0.0) | 4.37 (0.75) | 0.83 (0.04) | Cord | 13.7 (3.2) | 31.3 (1.4) | 27.4 (1.7) | 20.4 (8.9) |
| Brainstem | 11.7 (4.1) | 28.9 (1.9) | 23.1 (7.3) | 14.6 (7.9) | ||||||||
| Parotid R | 22.7 (5.4) | 54.4 (8.5) | 36.7 (8.0) | 23.5 (7.9) | ||||||||
| Parotid L | 23.1 (2.6) | 58.5 (5.4) | 35.4 (4.8) | 22.5 (4.7) | ||||||||
| Oral Cavity | 25.2 (1.7) | 52.7 (6.3) | 35.6 (4.4) | 27.5 (2.6) | ||||||||
| Larynx | 36.1 (5.7) | 59.3 (4.5) | 44.9 (4.3) | 37.0 (5.4) | ||||||||
| Body | 4.9 (0.4) | 44.2 (2.1) | 7.5 (2.5) | 0.2 (0.1) | ||||||||
| PTV 52 | PTV 56 | PTV 70 | Cord (μ) | Brainstem (μ) | Parotid R (μ) | Parotid L (μ) | Oral Cavity (μ) | Larynx (μ) | Body (μ) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D 95 | HI | D 95 | HI | HI | CI | ||||||||
| MP Boosted VMAT vs. Manual VMAT (p-value) | 0.172 | 0.345 | 0.916 | 0.345 | 0.074 | 0.916 | 0.345 | 0.600 | 0.115 | 0.345 | 0.027 | 0.074 | 0.027 |
| MP Boosted VMAT vs. MP VMAT (p-value) | 0.600 | 0.172 | 0.916 | 0.344 | 0.141 | 0.753 | 0.753 | 0.248 | 0.916 | 0.916 | 0.248 | 0.115 | 0.074 |
| MP VMAT vs. Manual VMAT (p-value) | 0.172 | 0.600 | 0.600 | 0.345 | 0.141 | 0.463 | 0.172 | 0.345 | 0.074 | 0.463 | 0.115 | 0.463 | 0.027 |