Table 1:

Discovery studies of genetics of CKD from populations with ancestries in resource poor regions of the World

Study	Population	Method	Phenotype	Loci/gene
Jarolim et al. Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11022–6.	South East Asia Cases: 30 Controls: 30	Positional cloning	Distal RTA and ovalocytosis syndrome	SLC4A1
Kopp et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008 Oct;40(10):1175–84.	African American Cases: 190 Controls: 222	MALD	FSGS ESKD	MYH9
Kao et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008 Oct;40(10):1185–92.	African American Cases: 1372 Controls: 806	MALD	Non-diabetic ESKD	MYH9
Genovese et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13;329(5993):841–5.	African American Cases: 205 Controls: 180	Fine mapping of MYH9 locus	FSGS ESKD	APOL1
Woo et al. Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. Ann Acad Med Singap. 2009 Oct;38(10):894–9.	South East Asian Cases: 28 Controls: 13	GWAS	IgA Nephropathy	GCM1 TNR TRDN
Nanayakkara et al. An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J Occup Health. 2014;56(1):28–38.	South Asian Cases: 311 Controls: 504	GWAS	CKD of unknown etiology	SLC13A3
Gbadegesin et al. HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome. J Am Soc Nephrol. 2015 Jul;26(7):1701–10	South Asian Cases: 214 Controls: 149	Exome association study	Childhood steroid Sensitive nephrotic syndrome	HLA-DQA1
Pungsrinont et al. Association between intelectin-1 variation and human kidney stone disease in northeastern Thai population. Urolithiasis. 2021 Dec;49(6):521–532	South East Asian Cases: 105 Controls: 105	GWAS	Kidney stone	ITLN1
Fatumo et al. Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans. Hum Mol Genet. 2021 Jul 28;30(16):1559–1568.	African Cases: 3,288 Controls: 8,224	GWAS	eGFR	GATM

Table showing the major discovery studies of genetic studies from resource poor regions of the world. RTA: renal tubular acidosis, GWAS-genome wide association studies, APOL1-ApoliporotienL1, egfr-estimated glomerular filtration rare, FSGS- focal sclerosing glomerulosclerosis. IgA-Immunoglobulin