Table 5.
Additive interaction between household chemical exposure and genotype. Stratified analysis assessing the interactions between household chemical exposure and presence of HLA-DRB1*15 alleles, absence of HLA-A*02, IL-6 SNP GG genotype, BCL2 SNP GG genotype and NFKB1 SNP GG genotype
| Household chemical exposure | Genetic exposure | N Case/ N Control | OR (95% CI) | RERI (95% CI) | AP (95% CI) |
|---|---|---|---|---|---|
| Exposure to Insect repellent | Presence of HLA-DRB1*15 | ||||
| − | − | 67/172 | reference | ||
| − | + | 44/45 | 2.92 (1.69 – 5.03)*** | ||
| + | − | 102/187 | 1.69 (1.12 – 2.53)* | ||
| + | + | 74/74 | 2.91 (1.82 – 4.66)*** | -0.69 (−2.47 – 1.09) | -0.23 (−0.88 – 0.40) |
| Exposure to Insect repellent | Absence of HLA-A*02 | ||||
| − | − | 35/73 | reference | ||
| − | + | 64/99 | 1.31 (0.76 – 2.24) | ||
| + | − | 64/92 | 1.50 (0.86 – 2.61) | ||
| + | + | 91/112 | 1.85 (1.09 – 3.12)* | 0.03 (−0.91 – 0.98) | 0.01 (−0.49 – 0.53) |
| Exposure to weed control products | Presence of HLA-DRB1*15 | ||||
| − | − | 109/280 | reference | ||
| − | + | 77/87 | 2.62 (1.74 – 3.93)*** | ||
| + | − | 61/94 | 2.42 (1.56 – 3.76)*** | ||
| + | + | 47/33 | 4.79 (2.72 – 8.43)*** | 0.74 (−1.89 – 3.38) | 0.15 (−0.32 – 0.64) |
| Exposure to weed control products | Absence of HLA-A*02 | ||||
| − | − | 74/130 | reference | ||
| − | + | 93/164 | 0.99 (0.65 – 1.49) | ||
| + | − | 32/37 | 1.80 (0.98 – 3.30) | ||
| + | + | 64/54 | 2.65 (1.60 – 4.39)*** | 0.86 (−0.54 – 2.26) | 0.32 (−0.13 – 0.78) |
| Exposure to weed control products | Presence of IL-6 SNP,GG |
||||
| − | − | 32/47 | reference | ||
| − | + | 129/229 | 0.77 (0.42 – 1.42) | ||
| + | − | 11/9 | 2.16 (0.69 – 6.74) | ||
| + | + | 84/81 | 1.84 (0.92 – 3.66) | -0.09 (−2.46 – 2.27) | -0.05 (−1.34 – 1.23) |
| Exposure to weed control products | Presence of BCL2 SNP, GG | ||||
| − | − | 63/104 | reference | ||
| + | − | 35/29 | 3.46 (1.78 – 6.71) | ||
| + | + | 57/60 | 2.36 (1.34 – 4.17)** | -1.38 (−3.64 – 0.87) | -0.58 (−1.59 – 0.42) |
| Exposure to weed control products | Presence of NFKB1 SNP, GG | ||||
| − | − | 114/199 | reference | ||
| − | + | 52/92 | 0.77 (0.48 – 1.21) | ||
| + | − | 62/69 | 1.86 (1.18 – 2.93)** | ||
| + | + | 34/21 | 3.32 (1.74 – 6.36)*** | 1.68 (−0.44 – 3.82) | 0.50 (0.13 – 0.88)** |
| Exposure to plant/tree insect control products | Presence of HLA-DRB1*15 | ||||
| − | − | 147/360 | reference | ||
| − | + | 110/115 | 2.33 (1.64 – 3.32)*** | ||
| + | − | 25/22 | 3.93 (2.01 – 7.71)*** | ||
| + | + | 19/13 | 5.08(2.23 – 11.57)*** | -0.19 (−4.95 – 4.57) | -0.03 (−0.99 – 0.92) |
| Exposure to plant/tree insect control products | Absence of HLA-A*02 | ||||
| − | − | 94/159 | reference | ||
| − | + | 130/212 | 1.03 (0.72 – 1.47) | ||
| + | − | 12/11 | 2.10 (0.81 – 5.42) | ||
| + | + | 26/13 | 4.93(2.23 – 10.88)*** | 2.79 (−1.34 – 6.94) | 0.56 (0.06 – 1.07) |
ref: reference group; RERI: Relative Excess Risk due to Interaction; AP: Attributable Proportion of disease; SI: Synergic Index; CI: Confidence Intervals
*
: P-value <0.05
**
: P-value <0.01
***
: P-value <0.00