Table 6.
Additive interaction between household chemical exposure and genotype sensitivity analysis: using inverse probability weighting). Stratified analysis assessing the interactions between household chemical exposure and presence of HLA-DRB1*15 alleles, absence of HLA-A*02, IL-6 SNP GG genotype, BCL2 SNP GG genotype and NFKB1 SNP GG genotype
| Exposureto Insect repellent | Presence of HLA-DRB1*15 | Case/ Control | OR (95% CI) | RERI (95% CI) | AP (95% CI) |
|---|---|---|---|---|---|
| − | − | 67/172 | reference | ||
| − | + | 44/45 | 2.94 (1.69 – 5.13)*** | ||
| + | − | 102/187 | 1.75 (1.15 – 2.65)* | ||
| + | + | 74/74 | 3.13 (1.93 – 5.05)*** | -0.56 (−2.40 – 1.27) | -0.18 (−0.79 – 0.43) |
| Exposure to Insect repellent | Absence of HLA-A*02 | ||||
| − | − | 35/73 | reference | ||
| − | + | 64/99 | 1.24 (0.71 – 2.17) | ||
| + | − | 64/92 | 1.48 (0.84 – 2.62) | ||
| + | + | 91/112 | 1.90 (1.10 – 3.27)* | 0.17 (−0.76 – 1.10) | 0.09 (−0.40 – 0.58) |
| Exposure to weed control products | Presence of HLA-DRB1*15 | ||||
| − | − | 109/280 | reference | ||
| − | + | 77/87 | 2.67 (1.77 – 4.02)*** | ||
| + | − | 61/94 | 2.50 (1.61 – 3.88)*** | ||
| + | + | 47/33 | 4.86 (2.72 – 8.67)*** | 0.68 (−2.03 – 3.40) | 0.14 (−0.35 – 0.63) |
| Exposure to weed control products | Absence of HLA-A*02 | ||||
| − | − | 74/130 | reference | ||
| − | + | 93/164 | 0.97 (0.63–1.47) | ||
| + | − | 32/37 | 1.76 (0.97–3.21) | ||
| + | + | 64/54 | 2.70 (1.61–4.51)*** | 0.96 (−0.43–2.36) | 0.35 (−0.07 – 0.79) |
| Exposure to weed control products | Presence of IL-6 SNP,GG |
||||
| − | − | 32/47 | reference | ||
| − | + | 129/229 | 0.76 (0.41–1.39) | ||
| + | − | 11/9 | 2.47 (0.73–8.30) | ||
| + | + | 84/81 | 1.83 (0.93–3.59) | -0.39 (−3.27 – 2.47) | -0.21 (−1.78 – 1.34) |
| Exposure to weed control products | Presence of BCL2 SNP, GG | ||||
| − | − | 63/104 | reference | ||
| − | + | 101/182 | 1.24 (0.78–1.97) | ||
| + | − | 35/29 | 3.40 (1.75–6.62)*** | ||
| + | + | 57/60 | 2.38 (1.34–4.22)** | -1.27 (−3.49 – 0.94) | -0.53 (−1.51 – 0.44) |
| Exposure to weed control products | Presence of NFKB1 SNP, GG | ||||
| − | − | 114/199 | reference | ||
| − | + | 52/92 | 0.75 (0.46 – 1.20) | ||
| + | − | 62/69 | 1.92 (1.21 – 3.05)** | ||
| + | + | 34/21 | 3.27 (1.74 – 6.13)*** | 1.60 (−0.44 – 3.64) | 0.48 (0.10 – 0.87)* |
| Exposure to plant/tree insect control products | Presence of HLA-DRB1*15 | ||||
| − | − | 147/360 | reference | ||
| − | + | 110/115 | 2.36 (1.65 – 3.36)*** | ||
| + | − | 25/22 | 4.06 (2.08 – 7.93)** | ||
| + | + | 19/13 | 5.33 (2.36 −12.02)*** | -0.09 (−5.03 – 4.84) | -0.02 (−0.95 – 0.92) |
| Exposure to plant/tree insect control products | Absence of HLA-A*02 | ||||
| − | − | 94/159 | reference | ||
| − | + | 130/212 | 1.02 (0.71 – 1.47) | ||
| + | − | 12/11 | 2.22 (0.83 – 5.98) | ||
| + | + | 26/13 | 5.08(2.36 – 10.94)*** | 2.82 (−1.41 – 7.06) | 0.56 (0.03 – 1.08) |
ref: reference group; RERI: Relative Excess Risk due to Interaction; AP: Attributable Proportion of disease; SI: Synergic Index; CI: Confidence Intervals
*
: P-value <0.05
**
: P-value <0.01
***
: P-value <0.0