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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2023 Feb 1;94(7):518–525. doi: 10.1136/jnnp-2022-330713

Table 8.

Models assessing multiplicative interactions for odds of POMS (sensitivity analysis: using inverse probability weighting)

Model Interaction term Exposure to toxic chemical, OR (95% CI) Secondary risk factors (DRB1*15 +, A*2 -, IL-6 GG+, BCL2 GG+, NFKB1 GG+),
OR (95% CI)
Interaction, OR (95% CI)
1 Exposure to Insect repellent for ticks or mosquitos X DRB1*15 1.75 (1.15–2.65)* 2.94 (1.69–5.11)*** 0.60 (0.30–1.22)
2 Exposure to Insect repellent for ticks or mosquitos X A*02 1.48 (0.84–2.62) 1.24 (0.71–2.17) 1.02 (0.50–2.09)
3 Exposure to weed control products X DRB1*15 2.50 (1.61–3.88)*** 2.67 (1.77–4.02)*** 0.72 (0.35–1.49)
4 Exposure to weed control products X A*02 1.76 (0.97–3.21) 0.96 (0.63–1.47) 1.58 (0.74–3.36)
5 Exposure to weed control products X IL-6 GG + 2.47 (0.73–8.30) 0.76 (0.41–1.39) 0.97 (0.27–3.46)
6 Exposure to weed control products X BCL2 GG + 3.40 (1.75–6.62)*** 1.24 (0.78–1.97) 0.56 (0.25–1.24)
7 Exposure to weed control products X NFKB1 GG + 1.92 (1.21–3.05) 0.75 (0.46–1.20) 2.26 (0.99–5.17)
8 Exposure to plant/tree insect or disease control products X DRB1*15 4.06 (2.08–7.93)*** 2.36 (1.65–3.36)*** 0.55 (0.19–1.60)
9 Exposure to plant/tree insect or disease control products X A*02 1.02 (0.71–1.47) 2.22 (0.83–5.98) 2.21 (0.64–7.65)

The logistic regression models were adjusted for age, sex, genetic ancestry, and mother’s education, recruiting site.

*

p-Value