Table 8.
Models assessing multiplicative interactions for odds of POMS (sensitivity analysis: using inverse probability weighting)
| Model | Interaction term | Exposure to toxic chemical, OR (95% CI) | Secondary risk factors (DRB1*15 +, A*2 -, IL-6 GG+, BCL2 GG+, NFKB1 GG+), OR (95% CI) |
Interaction, OR (95% CI) |
|---|---|---|---|---|
| 1 | Exposure to Insect repellent for ticks or mosquitos X DRB1*15 | 1.75 (1.15–2.65)* | 2.94 (1.69–5.11)*** | 0.60 (0.30–1.22) |
| 2 | Exposure to Insect repellent for ticks or mosquitos X A*02 | 1.48 (0.84–2.62) | 1.24 (0.71–2.17) | 1.02 (0.50–2.09) |
| 3 | Exposure to weed control products X DRB1*15 | 2.50 (1.61–3.88)*** | 2.67 (1.77–4.02)*** | 0.72 (0.35–1.49) |
| 4 | Exposure to weed control products X A*02 | 1.76 (0.97–3.21) | 0.96 (0.63–1.47) | 1.58 (0.74–3.36) |
| 5 | Exposure to weed control products X IL-6 GG + | 2.47 (0.73–8.30) | 0.76 (0.41–1.39) | 0.97 (0.27–3.46) |
| 6 | Exposure to weed control products X BCL2 GG + | 3.40 (1.75–6.62)*** | 1.24 (0.78–1.97) | 0.56 (0.25–1.24) |
| 7 | Exposure to weed control products X NFKB1 GG + | 1.92 (1.21–3.05) | 0.75 (0.46–1.20) | 2.26 (0.99–5.17) |
| 8 | Exposure to plant/tree insect or disease control products X DRB1*15 | 4.06 (2.08–7.93)*** | 2.36 (1.65–3.36)*** | 0.55 (0.19–1.60) |
| 9 | Exposure to plant/tree insect or disease control products X A*02 | 1.02 (0.71–1.47) | 2.22 (0.83–5.98) | 2.21 (0.64–7.65) |
The logistic regression models were adjusted for age, sex, genetic ancestry, and mother’s education, recruiting site.
p-Value