. 2023 Jun 15;13:9724. doi: 10.1038/s41598-023-36191-4

Table 2.

Gene ontology (GO) distribution of interested C. albicans genes regulated (> twofold) by ECQ.

Biological processes	Genes and expression level
Filamentous growth	*MAL2*	*HGC1*	*PGA59*	*ASC1*	*MSB2*	*PMT4*	*RNR1*	*RFX2*	*CAS4*	*GDA1*	*CHT2*	*FET34*	*ERG3*	*NOC2*
	*MTS1*	*YVH1*	*CSI2*	*KRE5*	*ALS1*	*GAL10*	*LHP1*	*TCC1*	*CDC19*	*RPS10*	*SLN1*	*KEL1*	*CDC28*	*ENP1*
	*BEM2*	*TEC1*	*PLD1*	*CDC5*	RTA4	RHB1	MRP2	STE23	SSN6	HAL9	CTA9	VPS23	RAP1	PPR1
	CTA4	GCN4	KAR3	ALO1	CAT8	BUD6	LYS14	FGR39	CRZ1	PCL5	FCR1	YHB1	RBF1
Organelle organization	*FAV1*	*CSP2*	*FLU1*	*ELF1*	*UTP18*	*NOP4*	*DBP7*	*SDA1*	*LTV1*	*HMI1*	*ENP2*	*NOC2*	*CIC1*	*MDJ2*
	*TSR1*	*VPS13*	*BUD22*	*FAA4*	*SEC12*	*SGD1*	*RPA135*	*HAC1*	*NTH1*	CSM3	ESP1	UBC4	MTR10	RTA4
	MAM33	VPS8	PTR3	PRO2	RAP1	PPR1	CAT8	MAS2	CCE1	AXL1	LYS4	MAS1	SSC1	HAP42
	PUT4	KAR9	MDJ1	ZCF8	TRP3	CSE4	MRR1	COX17	ZCF19	HSP60
Lipid metabolic process	*HGT7*	*FAS2*	*GDE1*	*DPP1*	*DPM1*	*FAS1*	*PMT4*	*ERG25*	*PGA38*	*IPP1*	*ERG3*	*WBP1*	*HXK2*	*PGA48*
	*MCD4*	*RNR21*	*FAD2*	*CNT*	*OST1*	*FAA4*	*OLE1*	*FAD3*	*DPM2*	*ERG4*	*PLB5*	*RHD1*	*CYK3*	*SCW11*
	ERG28	BMT5	COX15	ALK8	UPC2	EBP1	ESP1	AXL1	SAP3	ZCF19
Transport	*RBT5*	*AGC1*	*FLU1*	*ERV25*	*PET9*	*SDA1*	*CDR2*	*MDJ2*	*CNT*	*NMD3*	*SEC23*	*TIM17*	*MUP1*	*FAA4*
	*PGA63*	*SEC26*	UBC4	TIM8	MTR10	PAM17	MAM33	MAM33	NPL4	APG7	PRO2	TIM13	TIM22	LYS4
	MAS1	SSC1	MIA40	OPT4	COX17	HSP60	DUR3
Response to stress	*MET6*	*MSB2*	*RFX2*	*PHO84*	*TSA1B*	*CHK1*	*SOD5*	*GAL10*	*SLN1*	*SSK1*	PIM1	TTR1	PRX1	FDH3
Response to stress	PST3	SOD4	ALO1	HSP21	MPS1	HSP104	HSP60	YHB1	CIP1	GST2
Response to chemical	*SOD3*	*FET34*	*PTC2*	*MIG1*	*CDR2*	*CNT*	*HAC1*	*TRP99*	HAT1	FDH3	ALO1	HAP3	MPS1	YHB1
Response to chemical	CIP1	SSA2
Biofilm formation	*RBT5*	*CSA1*	*SAP5*	*PMT4*	*GCA2*	*ADH5*	*CAS4*	*RHR2*	*ALS1*	*PGA7*	SOH1	GCN4	MET4	ZCF8
Biofilm formation	IFD6	CRZ2
Signal transduction	*ASC1*	*RAS1*	*PHO84*	*GIN1*	*CDC5*	*STE4*	*PDE1*	*CEK2*	*SLN1*	*HAC1*	*CAG1*	*SSK1*	CRZ1	MPS1
Signal transduction	RGA2	REP1
Cell adhesion	*HWP1*	*RBT5*	*ALS3*	*YVC1*	*ASC1*	*GPD1*	*TRY6*	*IRA2*	*RHR2*	*BRG1*	*ALS4*	*ALS1*	*UME6*	*PHR1*
	*TOM1*	*PGA25*	*PGA63*	*ALS2*	*SSK1*	*ALS5*	*TEC1*	MIH1	HIS4	HWP2	ACE2	PGA55	CRZ2	MEP2
	PGA23	CRZ1	PGA28	SFU1
Cell wall organization	*CSP2*	*MSB2*	*PHR3*	*KRE5*	*HAC1*	RLM1	CEK1	PHR2
Hyphal growth	*HAC1*	*PHO84*	*ALS4*	*CDC28*	*CFL11*	*CLN3*	*ALS1*	GDT1	DBF2	CRZ1	RGA2
Cytoskeleton organization	*CDC28*	*CDC5*	DAD1	KAR3	KIP3	ASE1	TUB4	MYO1	KIP1	MPS1	DBF2	SPC19	IPL1	DAD2
Cytoskeleton organization	NUF2	NPL4	KAR9
Growth of unicellular organism as a thread of attached cells	*GAL10*	*STE4*	*CEK2*	*ASC1*	*YVC1*	RAP1	USO5	CTA4	HAL9	SOH1	MRR1	CAT8	WOR2
Cell cycle	*CDC28*	*CHT3*	*CLN3*	ESP1	DAD1	KIP3	KIP1	MPS1	DBF2	CSE4	SPC19	IPL1	DAD2	CBF1
Cell cycle	CRZ1	BUD31
Conjugation with cellular fusion	*PLD1*	*STE4*	*CEK2*	*CAG1*	KAR3	USO5
Cytokinesis	*MSB2*	*CHT3*	MYO1	CRZ1	MOB1	BUD31
Nucleus organization	*FAS2*	*CAG1*	SMC2	KAR3	USO5
Cell budding	*CLN3*	CRZ1
Pseudohyphal growth	RAP1

The genes were analyzed with https://www.ebi.ac.uk/QuickGO and classified by biological processes and labeled as bold (down-regulated expression) and underlined (up-regulated expression).