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. 2023 Jun 15;12:146. doi: 10.1038/s41377-023-01143-0

Table 2.

Characteristic of PDL fabrication technique. (a) Direct writing based, (b) interference lithography-based manufacturing, and (c) lithography-based

Description Laser direct witting Interference lithography Lithography
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Patterning Resolution

Tens of μm (pulse laser)

Hundreds of nm (fs laser)

Medium Hundreds of nm Medium Tens of nm High
Process Complexity Single step process, ambient environment, tunable laser and optomechanical parameters Low Single step process, ambient environment, tunable laser and optomechanical parameters Medium Multi-stage process, mask preparation, chemical etching High
Design Flexibility Digital pattern easily converted actual High Low capability to change of design. Complex optical setup to achieve interference Low Pre-mask preparation to convert to design to actual Medium
Productivity Single-point processing Low Large area processing High Large area processing High
Investment Cost Small-area facility with low environmental requirement, simple pattering equipment setup Medium Small-area facility with low environmental requirement, complex opto-mechanical setup (to cater irregular pattern) Medium Multi-equipment setup with high environmental and chemical management High