Fig. 4.

Effect of systemic administration (0.01–6 mg/kg i.p.) of MAM-2201 on the total distance traveled (a) and on the total immobility time (c) of mice. Overall effect observed in 4-h observation (b and d). Data are expressed as meters traveled (total distance traveled) and as seconds of immobility (total time immobile) and represent the mean ± SEM of 10 determinations for each treatment. Statistical analysis was performed by two-way ANOVA followed by the Bonferroni’s test for multiple comparisons for the dose response curve of MAM-2201. *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle