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. 2023 Jun 15;14(6):362. doi: 10.1038/s41419-023-05871-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The correlation between the expression of USP33 and TGFBR2 mRAN in TCGA-PAAD. B The expression of TGFBR2 in GEPIA database. C The expression of TGFBR2 and USP33 in PC patients derived tissues. D The correlation between the expression of USP33 and TGFBR2 protein in PC patients derived tissues. E The expression of TGFBR2 mRNA in PC cells transfected with USP33 shRNAs or overexpression plasmids. F The expression of TGFBR2 protein in PC cells transfected with USP33 shRNAs or overexpression plasmids. G The expression of TGFBR2 protein in PC cells transfected with different concentration of USP33 overexpression plasmids. H The expression of TGFBR2 protein in PC cells transfected with indicated plasmids and treated with CHX for indicated time. I The quantification of TGFBR2 expression in CHX treated PC cells. J The expression of TGFBR2 in PC cells treated with DMSO, CQ or MG-132 and transfected with USP33 shRNAs. K The colocalization between USP33 and lysotracker visualized by fluorescence microscope. L The Co-IP result of TGFBR2 and Rab11 in PC cells transfected with USP33 shRNA. M The Co-IP result of TGFBR2 and Rab5 in PC cells transfected with USP33 shRNA. N The Co-IP result of TGFBR2 and Rab7 in PC cells transfected with USP33 shRNA.