Table 3.
Associations between the Locus Coeruleus and Subjective Cognitive Decline (n=381).
| Outcomes: |
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|---|---|---|---|---|---|---|---|---|---|---|
| Subjective Cognitive Decline | Subjective Memory Decline | Subjective Executive Function Decline | Subjective Language Decline | Subjective Visuospatial Decline | ||||||
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| Predictors: | β (95%CI) | p * | β (95%CI) | p * | β (95%CI) | p * | β (95%CI) | p * | β (95%CI) | p * |
|
|
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| Participant-Rated Decline | ||||||||||
| Model 1a. Rostral-middle LCCNR |
−.18 (−.29 to −.07) | .001 | −.15 (−.26 to −.04) | .007 | −.16 (−.27 to −.05) | .005 | −.14 (−.25 to −.03) | .012 | −.15 (−.26 to −.04) | .010 |
| Caudal LCCNR | .02 (−.08 to .12) | .860 | −.0003 (−.10 to .10) | .995 | −.004 (−.11 to .10) | .946 | .04 (−.07 to .14) | .618 | .03 (−.08 to .13) | .789 |
| Young-adult Cognitive Ability | −.01 (−.11 to .09) | .860 | .001 (−.10 to .10) | .995 | .03 (−.07 to .13) | .906 | .02 (−.08 to .12) | .638 | −.10 (−.20 to .0003) | .128 |
| Age (years) | .08 (−.02 to .18) | .268 | .08 (−.02 to .18) | .195 | .03 (−.07 to .13) | .906 | .13 (.03 to .23) | .033 | −.003 (−.10 to .10) | .949 |
| Depressive Symptoms | .26 (.16 to .36) | <.001 | .20 (.10 to .30) | <.001 | .23 (.13 to .33) | <.001 | .25 (.15 to .35) | <.001 | .18 (.08 to .28) | .005 |
| Physical Morbidities | .09 (−.01 to .18) | .860 | .13 (.03 to .22) | .033 | .02 (−.08 to .12) | .906 | .08 (−.02 to .18) | .208 | .05 (−.05 to .15) | .612 |
| Informant-Rated Decline | ||||||||||
| Model 2a. Rostral-middle LCCNR |
−.10 (−.21 to .003) | .057 | −.01 (−.13 to .11) | .865 | −.05 (−.14 to .05) | .356 | −.01 (−.18 to .17) | .938 | −.03 (−.15 to .08) | .577 |
| Caudal LCCNR | .05 (−.05 to .15) | .713 | .06 (−.04 to .17) | .593 | .05 (−.04 to .14) | .433 | .10 (−.04 to .25) | .796 | .08 (−.02 to .18) | .373 |
| Young-adult Cognitive Ability | −.02 (−.12 to .09) | .844 | −.11 (−.21 to −.01) | .145 | −.07 (−.16 to .02) | .310 | −.02 (−.18 to .14) | .796 | −.06 (−.18 to .06) | .485 |
| Age (years) | −.01 (−.12 to .10) | .844 | .03 (−.08 to .14) | .658 | .10 (.01 to .19) | .135 | −.05 (−.21 to .12) | .796 | .09 (−.03 to .20) | .373 |
| Depressive Symptoms | −.03 (−.12 to .07) | .844 | .02 (−.07 to .12) | .658 | −.04 (−.13 to .05) | .465 | .02 (−.12 to .16) | .796 | −.04 (−.15 to .08) | .533 |
| Physical Morbidities | .07 (−.04 to .17) | .713 | −.02 (−.12 to .08) | .658 | .02 (−.07 to .10) | .666 | −.02 (−.19 to .14) | .796 | −.05 (−.18 to .07) | .485 |
Notes. CNR=contrast-to-noise ratio; LC=Locus Coeruleus. Each column represents an ECOG subscale regressed on predictors shown in the rows. Rows under “Participant-Rated Decline” show effects when predicting respective ECOG subscales using participant ratings; rows under the “Informant-Rated Decline” show effects when predicting respective ECOG subscales using informant ratings. Models were assessed in a general estimating equation accounting for related observations between twins in the same pair. Models were adjusted for age, depressive symptoms measured by the Center of Epidemiological Studies – Depression Scale (CESD), and physical morbidities.
P-values for effects outside of the hypothesized relationship with rostral-middle LC have been corrected for multiple testing using FDR.