. Author manuscript; available in PMC: 2024 Nov 1.

Published in final edited form as: J Biomol Struct Dyn. 2022 Dec 16;41(19):9808–9827. doi: 10.1080/07391102.2022.2153269

Table 1:

EGFR TKI Resistant Datasets

	Data Set 1³⁸	Data Set 2³⁵	Data Set 3⁴⁰	Data Set 4⁴⁰	Data Set 5³⁹	Data Set 6³⁶	Data Set 7³⁶	Data Set 8³⁶	Data Set 9³⁶	Data Set 10³⁶
Accession	GSE80802	GSE62118	GSE79688	GSE79688	GSE117610	GSE75602	GSE75602	GSE75602	GSE75602	GSE75602
CELLS LINE	HCC4006	HCC827	HCC827	HCC4006	PC9	PC9	PC9	PC9	PC9	PC9
EGFR TKI	Gefitinib	Erlotinib	Gefitinib	Gefitinib	Gefitinib	Gefitinib	Gefitinib	Gefitinib	Gefitinib	Gefitinib
MAX [C]	100nM	2uM	Up to 3uM	Up to 3uM	50nM	1mM	Not Specified	Not Specified	Not Specified	Not Specified
LENGTH OF TX	24 Hours	47 Days	Not Specified	Not Specified	6 Days	24 Hours	Not Specified	Not Specified	2 Weeks	2 Weeks
# of Samples (N)	Resistant (N=4) Control (N=4)	Resistant (N=2) Control (N=2)	Resistant (N=2) Control (N=2)	Resistant (N=2) Control (N=2)	Resistant (N=3) Control (N=2)	Resistant (N=2) Control (N=2)	Resistant (N=2) Control (N=2)	Resistant (N=2) Control (N=2)	Resistant (N=2) Control (N=2)	Resistant (N=2) Control (N=2)
# of DEGS	Up = 677 Down = 868	Up = 5,791 Down = 6,161	Up = 689 Down = 556	Up = 4,859 Down = 4,969	Up = 649 Down = 1,233	Up = 1,946 Down = 2,477	Up = 4,766 Down = 4,646	Up = 850 Down = 990	Up = 1,501 Down = 1,510	Up = 2,217 Down = 1,974

Raw RNA-SEQ datasets (.fasta files) were downloaded using the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database. Data was originally obtained by authors of the referenced manuscripts. Each dataset contains .fasta files for control cells and EGFR TKI resistant cells. This table details available information about the EGFR TKI used to make the resistant cell line, length of EGFR TKI treatment used to confer resistance, and the max EGFR TKI concentration that resistant cells were exposed to in their growth media. DEGs – differentially expressed genes (p < 0.05); TX – treatment.