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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Mass Spectrom Rev. 2022 Dec 16;43(4):683–712. doi: 10.1002/mas.21826

Figure 4:

Figure 4:

General flow chart for the two-tiered NBS patient testing for MPS involving a first-tier, high-throughput methodology performed via LC-MS/MS (shaded region) followed by a second-tier, more selective NBS technique. A first tier GAG screening could eliminate 99% of unaffected newborns giving rise to a valuable reduction in cost and time of more selective genetic tests. Figure adapted from Kubaski et al 2017.