Fig. 2.

Role of TRP channels in Parkinson's disease. PD causes the stimulation of TRPV1, TRPC1, and TRPC3 channels, as well as upregulates ROS formation. Initiation of TRPC1 triggers mitochondrial dysfunction. Inhibition of TRPV1 results in PD and upregulates ROS formation and inflammatory process. Initiation of TRP channels augments the intracellular Ca2+ levels, inflammatory response, and mitochondrial dysfunction, which eventually triggers the apoptotic cascade activation and neuronal loss in PD.