Fig. 3.

Role of TRP channels in Huntington's disease. HD leads to the stimulation of TRPC1 and TRPC5 channels and increases the generation of ROS via the influx of cations into the cell. Kir4.1 channel alters the K+ homeostasis and activates striatal astrocytes in mHTT protein, which causes hyperexcitability in neurons. Alteration in Ca2+ homeostasis leads to mitochondrial dysfunction and loss of synapsis in MSNs. TRPC1 and TRPC5 account for the excess influx of Ca2+ ions involved in Ca2+-dependent apoptosis in the striatum, which causes striatal neuronal loss and ultimately leads to HD.