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Role of TRP channels in Amyotrophic lateral sclerosis. In ALS, activation of voltage-gated Na + ion channels and decreased conduction of K+ ions causes hyperexcitability of axons. ROS generation causes SOD1 dysfunction, which disrupts the VDAC1 and causes mitochondrial-dependent apoptosis, and alteration in the Mg2+ ion homeostasis contributes to the etiology of ALS.
