TABLE 4.

Linear mixed effects model parameters for FA.

Fractional anisotropy	Parameter estimate (SE)	t	p
Left AF
Intercept	0.403 (0.003)	119.413	<2E-16***
Age	0.008 (0.001)	15.512	<2E-16***
Sex	0.002 (0.003)	0.764	0.446
Group	0.024 (0.009)	2.583	0.010*
Age*group	−0.003 (0.002)	−2.110	0.035*(0.07)
Right AF
Intercept	0.397 (0.006)	71.182	<2E-16***
Age	0.007 (0.001)	7.407	1.1E-12***
Sex	0.007 (0.005)	1.575	0.117
Group	−0.042 (0.016)	−2.578	0.010*
Age*group	0.005 (0.003)	1.925	0.055
Laterality index
Intercept	0.010 (0.007)	1.386	0.167
Age	0.001 (0.001)	0.812	0.418
Sex	−0.006 (0.005)	−1.040	0.300
Group	0.073 (0.021)	3.563	0.0004***
Age*group	−0.010 (0.004)	−2.840	0.005**(0.028)

Results are shown for linear mixed models comparing age-related brain changes between children with PAE and unexposed controls. Significant differences in the main effects are shown as: *(p < 0.05), **(p < 0.01), ***(p < 0.001). Significant differences in the age-group interactions that survived multiple comparison correction (q < 0.05) are bolded, with the corresponding q value in parentheses. Nominally significant age-group interactions that failed to survive multiple comparison correction are italicized, with the corresponding q value in parentheses. AF, arcuate fasciculus; SE, standard error.