Figure 3.

Sequence alignment of Envelope proteins ecto-domains (60 to 400 residues) of four dengue serotypes. Fully conserved amino acids are indicated with black stars (*) at the bottom of each row. Domains I, II, and III are schematically indicated with red, yellow, and blue color bars. Secondary structures are shown above the amino acid cluster (arrows indicate β strands, and the lines indicate helices). Each of the β strands of domains I, II, and III have been denoted with (A₀ to H₀), (a to l), and (A to G), respectively. The interacting residues of serotype-specific and cross-neutralizing antibodies are marked with blue and yellow shaded boxes, respectively, and their corresponding antibodies are mentioned above the bars with the same color-shed. The antibodies which were identified without any ADE effects are shown with blue letter code name and mentioned above the sequence alignment.