Figure 4.

Monoclonal antibodies targeting DENV E protein. Domains I, II, and III are schematically indicated with red, yellow, and blue colors, respectively. Antibodies in the light blue shed are serotype-specific that target mainly domain I, hinge between domain I and II, and lateral ridge of domain III. In contrast, the antibodies in the light-yellow color are cross-reactive and target mainly FL and bc loop of domain II and A strand of domain III. The antibodies which were identified without any ADE effects are shown with blue letter code name.