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. 2023 Jun 2;14:1200195. doi: 10.3389/fimmu.2023.1200195

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Copyright © 2023 Sarker, Dhama and Gupta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathogenesis and antibody-dependent dengue virus enhancing model. While antibodies of primary dengue virus infection bind to an infectious DENV particle during a subsequent infection with the homologous serotype, protective immunity is conferred. However, secondary dengue virus infection with alternative serotypes unable to completely neutralize the virus particle. Instead, the Ab–virus complex interacts to the Fc receptors (FcγR) on circulating monocytes, making it simpler for the virus to infect them, leads to increased viral replication and a higher risk of dengue with warning signs (DWS+)/severe dengue (SD).