Table 1.
DENV specific antibodies with their corresponding target epitopes, key interacting residues, neutralizing effects and ADE effects.
| Antibody | Target Virus | Epitope | Key interacting residues | Neutralizing effects | ADE effects | References |
|---|---|---|---|---|---|---|
| Antibodies targeting serotype specific epitope | ||||||
| DV1-E1 & E2 | DENV1 | DIII lateral ridge | LR(Q347, N348 & D360) | Neutralizes only DENV1 | NA | (54) |
| E106 | DENV1 | DIII lateral ridge | A(K307,K310);B(K325,Y326); BC(E327,T329,D330);K361,362 | Neutralizes 5 DENV-1 genotypes | NA | (55) |
| E111 | DENV1 | DIII & CC’ loop | N-terminal (300,301); C strand, CC’ loop (E345), C’ strand (334–351); EF loop (372);FG(382-384) | Neutralizes DENV-1 genotype 2 | NA | (56) |
| E105/E106 | DENV1 | DIII Lateral ridge | BC(G328, T329 & D330), DE (K361 & E362), & FG (K385) | Neutralizes 5 DENV-1 genotypes | Not tested | (57) |
| 1A1D-2 | DENV2 | DIII Lateral ridge | LR(K310) E383, P384 | Strongly neutralizes DENV2 | NA | (58) |
| 9D12 | DENV2 | Lateral ridge | LR(K310) E383, P384 | Moderately neutralizes DENV2 | Not tested | (58) |
| 3F9 | DENV2 | DI centre | DI-centre | Neutralizes DENV2 serotypes | NA | (59) |
| DV2-44, 76, 104 | DENV2 | DI & DII, DIII | DI & II(K88, Q233, H244); DV2-76_DIII(V309); DV2-104 _DIII(P334, M340,H346) | Neutralizes diverse DENV2 strain | Prevent ADE | (51) |
| 5H2 | DENV4 | DI (F0, G0 and H0 and G0H0) | DI(E172, K174, P176, D177, E180, R293) | Neutralizes DENV4 | NA | (60) |
| 1G6 | DENV4 | EDIII | EDIII (387-ALTLH-390) T388, H390 | Neutralize DENV4 | Not mentioned | (61) |
| 3H2 | DENV-2 | EDIII | DIII-DI hinge residues (298–303) BC loop (328–332), K361,V282, E383, P384 & C strand, CD loop | Neutralizes DENV2 | Marginal ADE | (62) |
| 2C8 | DENV-2 | EDIII | DIII-DI hinge residues (298-303) BC loop (328-332), K361,V282, E383, P384 | Neutralizes DENV2 | Induce ADE | (63) |
| DENV-290 | DENV-2 | EDII | EDII | Neutralizes DENV3 | Not mentioned | (62) |
| Antibodies targeting cross-reactive epitope | ||||||
| 7F4 | DENV-1,2,4 | EDII | DII (E67, E69 and E118) | Cross-reactive but neutralizes DENV1 | Undetected | (46) |
| E53 | WNV, DENV1-4 | EDII fusion loop | WNV_FL(G104, C105, G106, L107, G109,K110); bc(C74, T76, M77, G78, E79) | Cross-reactive | Prevailing ADE | (64) |
| m366.6 | DENV1-4 | DIII A strand | DIII_A(K310) | Cross-neutralizing | Undetectable level | (65) |
| 3E31 | DENV1-4 | DIII | AB (314–370), E(365-370), Q316, H317, E368, E370 | Cross-neutralizing | Does not promote | (66) |
| Ab513 (4E5A) | DENV1-4 | DIII | DE(358-365),Y360, S363 | Broadly neutralizing | Undetectable level | (67) |
| VIS513 (4E11) | DENV1-4 | DIII A strand | DIII_A(K310, E311) | Cross-neutralizing | Minor level | (68) |
| 2H12 | DENV1-4 | DIII A strand | A(314-317); FL(K110, E114, T115, Q116, H117) | Cross-neutralizing except DENV2 | Minor or negative | (63) |
| 9F12 | WNV, DENV1-4 | DIII A strand | A(K305,K307, K310); B(327-331) | Cross-neutralizing | Not mentioned | (69) |
| N297Q-B3B9 | DENV1-4 | DII fusion loop | Fusion loop | Cross-neutralizing | Lack of ADE | (70) |
| SigN-3C | DENV1-4 | DII fusion loop & DIII | FL(G100, W101); EDIII(K310) | Cross-neutralizing | Abrogates ADE | (71) |
| 2A10G6 | DENV1-4 | DII fusion loop | ZIKV, DENV1-4 FL(98D,99R,100X,101W) | Cross-neutralizing | Undetected | (72, 73) |
| 1C19 | DENV1-4 | DII-bc loop | DII-bc(R73,G78,E79) | Cross-neutralizing | Undetected | (74) |
| d448 | DENV1-4 | DII and M | DII (D215, P219, M237, Q256, and G266) | Cross-neutralizing | Undetected | (75) |
| DM25-3 | DENV1-4 | VLPs | DII-FL(W101) | Cross-neutralizing | Undetected | (76) |
| Z004 | ZIKV DENV1 |
DIII lateral ridge | LR(P384, G385) | Neutralizes ZIKV and DENV1 | Not tested | (77) |
| MZ4 | ZIKV DENV2 |
DIII & DI linker | ZIKV(residues 299-306) | Neutralizes ZIKV and DENV2 | Lesser extend | (78) |
| Antibodies targeting quaternary epitope | ||||||
| HM14c10 | DENV1 | Hinge region between DI- DII & DIII | DI(I161, T165, Q167,E172); DII(S273, G274,T275,T276); DIII(E311,E309,E327) | Potentially neutralizes DENV1 | Not mentioned | (79) |
| 5J7 | DENV3 | DI–DII HR & DIII, FL loop | DI & DII (E123, E126, HR-Q269, N270) EDIII(K307, K308) | Neutralizes DENV3 | Not mentioned | (80) |
| 1F4 | DENV1 | DI & DI-DII HR of one ED1 and DIII of ED2 | Doa; Eo, EoFo loop, Fo (155–165), Go strand, GoHo loop (170–177), and kl loop (272–276) | Strongly neutralizes DENV1 | Not mentioned | (81) |
| 2D22 | DENV2 | Dimer of DIII; and DII | DIII(R323) & EDII (FL and bc loop) | Neutralizes DENV2 | Prevent ADE | (82) |
| 1L12 | DENV2 | DIII | DIII(R323) | Neutralizes DENV2 | Not mentioned | (59) |
| A11, B7, C8, C10 | DENV2 | Dimer of EDI & EDII | DI(148-159, N153 glycan); DII(67-74, N67 glycan), FL loop (97-106), ij loop (246-249) | Neutralizes DENV1-4 | Not mentioned | (83) |
| J8, J9 | DENV1-4 | DI | DI (K47,H149, V151, F279) | Cross-neutralizing | No ADE | (84) |
NA, Not Available.