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. 2023 Jun 2;15:1161405. doi: 10.3389/fnagi.2023.1161405

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Copyright © 2023 Li, Lu, Zhao, Lu and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug repurposing method based on the AIM. (A) Diagram demonstrated the average PPI network proximity calculation method from all drug targets to module hub genes (e.g., X = 3, Y = 10). (B) Quantile-Quantile plot (QQ plot) indicated background distribution based on random pseudo-targets conformed to Gaussian distribution well. (C) Gray density plot represents background distribution based on random three pseudo-targets and the red dashed curve represents fitted Gaussian distribution. The brown line indicated the actual proximity of the drug. (D) The scatter plot showed the rank of 1,084 approved drugs based on the adjusted p-value.