Table 2.
Top 20 repurposing drugs according to significantly close PPI network proximity.
| Rank | Drug ID | Drug name | Background distribution (Targets|Mean|SD) | Proximity | Padj | Literature |
|---|---|---|---|---|---|---|
| 1 | D0H0EQ | Ponatinib | 53|2.867|0.056 | 2.428 | 1.95E-12 | No |
| 2 | D09KTS | Ibrutinib | 30|2.868|0.073 | 2.330 | 5.59E-11 | Yes |
| 3 | D0O0LS | Entrectinib | 47|2.868|0.059 | 2.453 | 2.53E-10 | No |
| 4 | D0E6XR | Dasatinib | 95|2.867|0.041 | 2.627 | 5.97E-07 | Yes |
| 5 | D0G6QF | Vandetanib | 62|2.867|0.051 | 2.605 | 3.60E-05 | No |
| 6 | D0J5VR | Idelalisib | 7|2.875|0.156 | 2.100 | 6.64E-05 | No |
| 7 | D0Q9EV | Lifitegrast | 3|2.874|0.233 | 1.733 | 7.90E-05 | No |
| 8 | D03ZBT | Crizotinib | 106|2.867|0.039 | 2.678 | 9.25E-05 | No |
| 9 | D0IQ6P | Cabozantinib | 22|2.867|0.086 | 2.459 | 1.21E-04 | No |
| 10 | D0S5LD | BAY 80-6946 | 6|2.875|0.172 | 2.067 | 1.33E-04 | No |
| 11 | D04LVK | Ceritinib | 23|2.868|0.084 | 2.487 | 2.80E-04 | No |
| 12 | D09GDD | Regorafenib | 24|2.869|0.082 | 2.500 | 3.21E-04 | Yes |
| 13 | D09HNV | Intedanib | 163|2.867|0.03 | 2.736 | 5.42E-04 | No |
| 14 | D0RU0O | IPI-145 | 5|2.873|0.188 | 2.060 | 5.42E-04 | No |
| 15 | D0W7HE | Alpelisib | 5|2.873|0.188 | 2.060 | 5.42E-04 | No |
| 16 | D0K8KX | Quercetin | 34|2.868|0.068 | 2.579 | 6.51E-04 | Yes |
| 17 | D0V9WF | Lestaurtinib | 276|2.867|0.023 | 2.770 | 6.51E-04 | No |
| 18 | D0W5HK | Sorafenib | 74|2.867|0.047 | 2.666 | 6.51E-04 | Yes |
| 19 | D01PZD | Romiplostim | 11|2.873|0.125 | 2.345 | 7.25E-04 | No |
| 20 | D0OB0F | Bosutinib | 122|2.867|0.036 | 2.717 | 7.30E-04 | Yes |