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. 2023 Jun 2;10:1202380. doi: 10.3389/fmed.2023.1202380

Table 2.

The parameters of IOS, spirometry, 6MWT and CAT score at 0-, 12-, and 24-week.

0-week (Baseline) 12-week 24-week p-value (0–12 week) p-value (12–24 week) p-value (0–24 week)
R5, cmH20/L/s 5.97 (4.90–7.67)b 5.82 (4.69–7.67)b 5.60 (4.27–7.42)b 0.008 c 0.007 c <0.001 c
R5, %pred 192.49 (170.65–253.16)b 191.32 (158.64–245.34)b 173.26 (143.55–240.55)b 0.007 c 0.007 c <0.001 c
R20, cmH20/L/s 3.25 (2.89–3.83)b 3.18 (2.81–3.97)b 3.07 (2.71–3.71)b 0.488c 0.040 c 0.049 c
R5–R20, cmH20/L/s 2.69 (2.06–4.19)b 2.54 (1.74–3.88)b 2.45 (1.64–3.40)b 0.021 c 0.014 c <0.001 c
AX, cmH20/L 28.88 (21.28–41.55)b 26.67 (20.62–38.83)b 25.07 (15.90–38.11)b 0.293c 0.066c 0.072c
X5, cmH20/L/s −3.47 (SD 1.40)a
−3.41 (−4.39 to −2.44)b 		−3.52 (−4.37 to −2.50)b −3.26 (SD 1.34)a
−3.31 (−4.25 to −2.23)b 		0.854c 0.085c 0.214d
FEV1/FVC, % 52.31 (44.67–61.67)b 53.00 (47.00–64.00)b 55.00 (47.50–65.00)b 0.008 c 0.950c <0.001 c
FEV1, L 1.22 (SD 0.41)a 1.29 (SD 0.45)a 1.35 (SD 0.48)a 0.018 d 0.182d 0.001 d
FEV1, %pred 52.15 (SD 15.65)a 54.78 (SD 16.39)a 57.27 (SD 17.31)a 0.025 d 0.118d 0.001 d
FVC, L 2.35 (SD 0.74)a
2.23 (1.78–2.79)b 		2.36 (SD 0.72)a
2.34 (1.84–2.84)b 		2.31 (1.98–2.96)b 0.938d 0.183c 0.475c
FVC, %pred 67.87 (SD 18.81)a
63.5 (54.25–80.00)b 		68.13 (SD 17.75)a
66.00 (53.00–79.50)b 		68.0 (57.50–79.50)b 0.975d 0.137c 0.311c
FEF25–75, L 0.46 (0.35–0.82)b 0.55 (0.38–0.76)b 0.57 (0.39–0.94)b 0.023 c 0.545c 0.002 c
FEF25–75, %pred 22.00 (15.00–34.50)b 25.00 (16.25–32.00)b 27.00 (17.50–39.00)b 0.024 c 0.260c <0.001 c
6MWT, meter 213.23 (SD 88.78)a 221.89 (SD 92.86)a 243.09 (SD 103.33)a 0.267d 0.043 d 0.016 d
CAT score 19.43 (SD 7.10)a
19.00 (15.00–24.00)b 		13.46 (SD 5.98)a
14.00 (9.25–16.75)b 		9.00 (7.00–14.00)b <0.001 d < 0.001 c < 0.001 c
a

Mean (SD).

b

Median (IQR).

c

Wilcoxon signed ranks test.

d

Paired t-test.Bold indicates statistically significant.