Figure 5.
Microbiome changes by induction of constipation and intake of multi-strain probiotics Consti-Biome. (A) Is the representative phylum increase and decrease. (B,C) Are variations of the family Erysipelotrichaceae and the genus Akkermansia, respectively. (D,E) Exhibit the alpha-diversity beta-diversity, respectively. Microbiome of normal control (NOR), loperamide administration (LOP), positive control (PC), low concentration multi-strain probiotics administration (G1, 2 × 108 cfu/mL), medium concentration multi-strain probiotics administration (G2, 2 × 109 cfu/mL), and high concentration probiotic administration (G3, 2 × 1010 cfu/mL) groups were analyzed with fecal samples 2 weeks after treatment with multi-strain probiotics. Data are mean ± SEM of 5 animals in B and C. *p < 0.05, significantly different from the LOP as per one-way ANOVA with the Tukey’s post-test.