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. 2023 Jun 2;14:1139391. doi: 10.3389/fimmu.2023.1139391

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Copyright © 2023 Ding, Sheriff, Sontz and Merchant

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single cell transcriptional profiling of Slfn4+ immune cells from mouse stomachs. (A) Stomach single cell Slfn4 gene expression was color coded for 3 subsets STS4-1(Maize), STS4-2(red) and STS4-3 (blue). The boxed area with Slfn4 gene expression was enlarged on the right. Violin plots depict Slfn4 expression levels (log2 transformation) in each subset. (B) Representative up-regulated genes color-coded fold-change expression levels (gray to red of 12 representative genes in Slfn4⁺ -MDSCs). (C) GO enrichment analysis of upregulated genes in stomach Slfn4 ⁺ vs Slfn4 ^- immune cells. The top 10 significantly enriched GO (−log10 (p-value)) terms of molecular functions and biological process were shown. Upregulated genes in Slfn4⁺ were identified by 10x Loupe browser with (log2 FC>0.58, FDR ≤ 0.05) relative to Slfn4^- cells. (D) Heatmap of DEGs between 3 subsets of STS4. Representative enriched genes in each subset were indicated. The color scale is from log2 FC-10 (blue) to log2 FC 10 (red). DEGs were identified by 10X Loupe browser (FDR ≤ 0.05) relative to all the other subsets.