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. 2023 Jun 2;14:1130925. doi: 10.3389/fphys.2023.1130925

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Copyright © 2023 Linninger, Barua, Hang, Iadevaia and Vakilynejad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the model fit with individual ASO PK data (Monine et al., 2021). (A) Plasma concentration-time profile over 7 days following IT administration of a single 12 mg dose. (B) CSF concentration-time profile in the lumber region over 7-day following IT administration of a single 12 mg dose. (C) Plasma concentration-time profile following IT administration of three repeated 12 mg doses applied at 2-week intervals. (D) CSF concentration-time profile in the lumbar region following IT administration of three repeated 12 mg doses applied at 2-week intervals.