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. 2023 Jun 2;14:1130925. doi: 10.3389/fphys.2023.1130925

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Copyright © 2023 Linninger, Barua, Hang, Iadevaia and Vakilynejad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined effects of infusion volume and time on tissue distribution. Each panel corresponds 8,000 simulations each for a distinct combination of infusion time and infusion volume randomly sampled from the range specified by the X-and Y-axis, respectively. The color map indicates relative concentrations. (A) and (B) represent the thoracic region spinal tissue, (C) and (D) represent the cranial tissue at the indicated times. In all simulations, time zero is marked by the start of the infusion. A fixed amount (12 mg) ASO was considered regardless of the infusion volume or infusion time.