Skip to main content
. 2023 Jun 2;13:1181660. doi: 10.3389/fonc.2023.1181660

Figure 2.

Figure 2

Computational modeling predicts that DLBCL cell lines of the same cell of origin have distinct basal RelA activity. (A) Expression of NFKB1 (encoding p105/p50) and NFKB2 (encoding p100/p52) in published gene expression data (GSE103934) for a library of DLBCL cell lines (53). ABC/GC-DLBCL is indicated in red and blue respectively. (B, C) Nuclear RelA:p50 (B) and cRel:p50 (C) concentration in computational simulations using gene expression values to scale the expression of NF-κB components and create cell line-specific models. Steady state abundances are shown on the left, with TME-activated time course responses shown on the right. Mean and standard deviation of 25 single cell simulations is indicated.