Fig. 5.

(a) Pairwise comparisons between complete bla _KPC-2-encoding IncN plasmids demonstrate substantial plasticity despite high nucleotide similarity among shared backbone regions. The plasmids include a previously published sequence (GenBank accession no. KY271414) [48] and six from the PHW collection. ORFs are depicted as arrows with resistance genes (including bla _KPC-2) labelled. Grey blocks between plasmid pairs indicate regions of homology. The colour of the ORFs represents the percentage nucleotide similarity to the plasmid from ARGID_28504 via blastn. (b) Conserved genetic environment of bla _KPC-2 among the IncN plasmids.