TABLE 3.
Effect of NDM on fasting blood glucose (FBG) levels in CC female mouse lines maintained on standard chow diet (CHD) for 12 weeks, and subsequently treated with NDM for six more weeks while maintained on the same diet. Summary of FBG (mg/dL) of female mice of 13 different of CC lines at age 8 weeks (w0 of the beginning of the experiment), at 12 weeks after maintaining on CHD (w12 + SE), changes in FBG (ΔFBG) between week 12 and week zero ((ΔFBG) (w0–12 + SE)) and %FBG changes between this period including standard error (% change ± SE) and indicating the significance status (S), FBG after 6 weeks treatment with NDM FBG (w18 ± SE), differences in %FBG changes (ΔFBG(w12–18 + SE)) between weeks 18 and 12, percentage of FBG changes between this period including standard error (% change ± SE) and indicating significant (S) or non‐significant (NS) status
| Females | CHD group | FBG ± SE | Week 0 to 12 | Week 12 to 18 | ||||
|---|---|---|---|---|---|---|---|---|
| Line | No. of mice | Wk0 | Wk12 | ΔFBG | (% change ± SE)s | CRE FBG wk18 ± SE | ΔCRE FBG ± SE | (% change ± SE)s |
| IL72 | 5 | 146.00 ± 5.91 | 128.40 ± 8.12 | −17.60 ± 10.35 | (−11.45 ± 6.90)ns | 128.80 ± 4.47 | 0.40 ± 5.77 | (1.27 ± 4.76)ns |
| IL111 | 6 | 86.67 ± 5.84 | 89.17 ± 10.56 | 2.50 ± 9.33 | (2.87 ± 10.58)ns | 70.33 ± 4.45 | −18.83 ± 7.87 | (−16.83 ± 8.22)ns |
| IL521 | 1 | 137.00 ± 0.00 | 117.00 ± 0.00 | −20.00 ± 0.00 | 14.6 ± 0.00 | 120.00 ± 0.00 | 3.00 ± 0.00 | 2.56 ± 0.00 |
| IL1912 | 7 | 183.29 ± 9.78 | 141.86 ± 6.40 | −41.43 ± 10.09 | (−21.58 ± 4.97)s | 163.14 ± 8.24 | 21.29 ± 10.57 | (16.41 ± 8.38)ns |
| IL5000 | 5 | 145.40 ± 8.00 | 109.80 ± 6.76 | −35.60 ± 6.47 | (−24.13 ± 3.90)s | 109.00 ± 8.19 | −0.80 ± 5.11 | (−0.66 ± 4.82)ns |
| IL5001 | 8 | 140.50 ± 4.79 | 121.88 ± 4.23 | −18.63 ± 7.11 | (−12.36 ± 4.76)s | 117.50 ± 3.28 | −4.38 ± 4.87 | (−2.90 ± 3.97)ns |
| IL5003 | 4 | 132.00 ± 2.86 | 137.00 ± 13.87 | 5.00 ± 16.46 | (4.54 ± 12.66)ns | 90.75 ± 5.07 | −46.25 ± 9.04 | (−32.78 ± 3.46)s |
| IL5004 | 7 | 110.71 ± 12.67 | 110.71 ± 3.23 | 0.00 ± 10.84 | (10.03 ± 16.29)ns | 105.43 ± 5.85 | −5.29 ± 8.46 | (−3.66 ± 7.54)ns |
| IL5008 | 1 | 106.00 ± 0.00 | 150.00 ± 0.00 | 44.00 ± 0.00 | 41.51 ± 0.00 | 108.00 ± 0.00 | −42.00 ± 0.00 | (−28.00 ± 0.00)ns |
| IL5020 | 4 | 143.25 ± 6.52 | 134.00 ± 22.00 | −9.25 ± 15.68 | (−8.01 ± 11.60)ns | 97.50 ± 8.74 | −36.50 ± 19.48 | (−22.29 ± 11.14)ns |
| IL5023 | 5 | 115.00 ± 4.91 | 105.00 ± 2.63 | −10.00 ± 3.39 | (−8.34 ± 2.63)s | 78.20 ± 6.83 | −26.80 ± 7.81 | (−25.18 ± 7.52)s |
| IL6009 | 5 | 126.40 ± 6.04 | 111.80 ± 6.69 | −14.60 ± 1.57 | (−11.73 ± 1.48)s | 132.20 ± 7.30 | 20.40 ± 7.04 | (19.14 ± 6.67)s |
| IL6020 | 5 | 108.60 ± 5.94 | 107.60 ± 3.20 | −1.00 ± 6.75 | (0.16 ± 5.72)ns | 101.40 ± 2.32 | −6.20 ± 4.02 | (−5.44 ± 3.43)ns |
| ILTotal | 63 | 131.00 ± 3.90 | 118.13 ± 2.93 | −12.87 ± 3.26 | (−6.78 ± 2.85)s | 110.65 ± 3.66 | −7.48 ± 3.35 | (−5.32 ± 2.64)s |