TABLE 4.
Effect of NDM on fasting blood glucose (FBG) levels in CC female mouse lines maintained on a high‐fat diet (HFD) for 12 weeks, and subsequently treated with NDM for six more weeks while maintained on the same diet. Summary of FBG (mg/dl) of female mice of 13 different of CC lines at age 8 weeks (w0 of the beginning of the experiment), at 12 weeks after maintaining on HFD (w12 + SE), changes in FBG (ΔFBG) between weeks 12 and week zero (ΔFBG) of (w0–12 + SE) and %FBG changes between this period including standard error (% change ± SE) and indicating the significant status (S), FBG after 6 weeks treatment with NDM FBG (w18 ± SE), differences in %FBG changes (ΔFBG (w12–18 + SE)) between weeks 18 and 12, percentage of FBG changes between this period including standard error (% change ± SE) and indicating the significant (S) or non‐significant (NS) status
| Females | HFD group | FBG ± SE | Week 0–12 | CRE FBG wk18 ± SE | Week 12–18 | |||
|---|---|---|---|---|---|---|---|---|
| Line | n = no of mice | Wk0 | Wk12 | ΔFBG | (% change ± SE)s | ΔCRE FBG ± SE | (% change ± SE)s | |
| IL72 | 7 | 108.86 ± 5.34 | 138.86 ± 5.56 | 30.00 ± 9.57 | (30.27 ± 9.96)s | 94.57 ± 3.58 | −44.29 ± 7.23 | (−31.11 ± 4.29)s |
| IL111 | 5 | 93.60 ± 4.53 | 84.00 ± 3.54 | −9.60 ± 7.67 | (−8.71 ± 8.30)ns | 102.00 ± 9.07 | 18.00 ± 10.49 | (22.80 ± 13.64)ns |
| IL521 | 4 | 147.50 ± 8.51 | 122.00 ± 5.05 | −25.50 ± 11.82 | (−16.12 ± 7.65)ns | 134.25 ± 13.33 | 12.25 ± 9.84 | (9.58 ± 7.64)ns |
| IL1912 | 7 | 154.14 ± 6.30 | 167.14 ± 4.37 | 13.00 ± 7.96 | (9.50 ± 5.29)ns | 145.71 ± 6.29 | −21.43 ± 7.86 | (−12.43 ± 4.57)s |
| IL5000 | 4 | 140.50 ± 7.42 | 145.25 ± 4.33 | 4.75 ± 3.20 | (3.75 ± 2.36)ns | 145.50 ± 5.32 | 0.25 ± 8.58 | (0.62 ± 5.90)ns |
| IL5001 | 11 | 124.09 ± 3.44 | 142.91 ± 8.65 | 18.82 ± 10.25 | (16.57 ± 8.11)ns | 145.27 ± 7.25 | 2.36 ± 9.75 | (5.23 ± 8.09)ns |
| IL5003 | 9 | 144.11 ± 6.55 | 132.44 ± 4.03 | −11.67 ± 4.86 | (−7.08 ± 3.46)ns | 154.56 ± 3.95 | 22.11 ± 2.83 | (17.02 ± 2.47)s |
| IL5004 | 4 | 106.00 ± 5.40 | 116.00 ± 2.04 | 10.00 ± 7.07 | (10.47 ± 7.00)ns | 161.50 ± 10.99 | 45.50 ± 12.21 | (39.61 ± 10.80)s |
| IL5008 | 5 | 112.80 ± 3.46 | 112.20 ± 5.45 | −0.60 ± 5.24 | (−0.39 ± 4.68)ns | 131.40 ± 8.94 | 19.20 ± 11.51 | (18.52 ± 10.65)ns |
| IL5020 | 5 | 133.80 ± 0.92 | 134.40 ± 7.11 | 0.60 ± 6.99 | (0.44 ± 5.24)ns | 121.60 ± 8.89 | −12.80 ± 12.08 | (−8.23 ± 9.20)ns |
| IL5023 | 7 | 110.57 ± 2.59 | 136.29 ± 8.63 | 25.71 ± 8.12 | (23.27 ± 7.25)s | 139.71 ± 6.19 | 3.43 ± 9.54 | (4.33 ± 6.09)ns |
| IL6009 | 3 | 114.33 ± 9.24 | 126.33 ± 14.52 | 12.00 ± 22.59 | (13.77 ± 22.24)ns | 105.67 ± 22.02 | −20.67 ± 7.80 | (−18.03 ± 7.78)ns |
| IL6020 | 9 | 130.33 ± 6.99 | 110.89 ± 2.78 | −19.44 ± 6.82 | (−12.95 ± 5.19)s | 131.11 ± 7.18 | 20.22 ± 6.91 | (18.47 ± 6.54)s |
| ILTotal | 80 | 125.88 ± 2.44 | 130.29 ± 2.78 | 4.41 ± 3.01 | (5.42 ± 2.52)s | 133.58 ± 2.96 | 3.29 ± 3.42 | (5.16 ± 2.77)ns |