TABLE 6.
Effect of NDM on fasting blood glucose (FBG) levels in CC male mouse lines maintained on a high‐fat diet (HFD) for 12 weeks, and subsequently treated with NDM for six more weeks while maintained on the same diet
| Males | HFD group | FBG ± SE | Week 0–12 | CRE FBG wk18 ± SE | Week 12–18 | |||
|---|---|---|---|---|---|---|---|---|
| Line | n = no of mice | Wk0 | Wk12 | ΔFBG | (% change ± SE)s | ΔCRE FBG ± SE | (% change ± SE)s | |
| IL72 | 10 | 145.70 ± 2.52 | 159.90 ± 6.91 | 14.20 ± 6.69 | (9.86 ± 4.62)ns | 98.40 ± 4.84 | −61.50 ± 6.75 | (−37.90 ± 3.20)s |
| IL111 | 4 | 107.50 ± 6.61 | 109.50 ± 5.55 | 2.00 ± 10.46 | (3.65 ± 11.09)ns | 66.25 ± 3.84 | −43.25 ± 8.05 | (−38.74 ± 6.10)s |
| IL521 | 4 | 156.75 ± 9.25 | 110.50 ± 8.72 | −46.25 ± 17.78 | (−27.81 ± 9.81)ns | 110.25 ± 12.15 | −0.25 ± 14.51 | (1.33 ± 12.38)ns |
| IL1912 | 9 | 182.33 ± 7.08 | 203.67 ± 6.78 | 21.33 ± 11.56 | (13.33 ± 6.45)ns | 159.78 ± 5.64 | −43.89 ± 6.09 | (−21.29 ± 2.58)s |
| IL5000 | 8 | 146.25 ± 4.64 | 166.75 ± 6.51 | 20.50 ± 8.44 | (14.97 ± 6.45)s | 131.00 ± 8.77 | −35.75 ± 11.18 | (−20.49 ± 6.44)s |
| IL5001 | 7 | 144.14 ± 2.40 | 127.14 ± 9.70 | −17.00 ± 8.20 | (−12.10 ± 5.63)ns | 136.29 ± 11.08 | 9.14 ± 10.82 | (9.12 ± 9.45)ns |
| IL5003 | 7 | 149.86 ± 8.68 | 167.71 ± 14.60 | 17.86 ± 13.42 | (12.48 ± 9.75)ns | 152.29 ± 4.94 | −15.43 ± 14.19 | (−4.43 ± 9.94)ns |
| IL5004 | 5 | 132.20 ± 13.75 | 112.20 ± 4.66 | −20.00 ± 15.07 | (−11.28 ± 9.86)ns | 146.80 ± 5.55 | 34.60 ± 5.02 | (31.31 ± 5.15)s |
| IL5008 | 4 | 122.75 ± 3.12 | 125.00 ± 10.59 | 2.25 ± 9.93 | (1.78 ± 8.10)ns | 143.25 ± 3.07 | 18.25 ± 10.18 | (16.67 ± 8.34)ns |
| IL5020 | 5 | 241.80 ± 20.61 | 178.40 ± 27.09 | −63.40 ± 26.18 | (−25.64 ± 10.74)ns | 218.60 ± 24.04 | 40.20 ± 19.68 | (28.04 ± 13.09)ns |
| IL5023 | 4 | 143.00 ± 5.67 | 200.50 ± 15.11 | 57.50 ± 12.28 | (40.10 ± 8.12)s | 200.50 ± 17.73 | 0.00 ± 20.55 | (1.46 ± 11.42)ns |
| IL6009 | 4 | 135.75 ± 10.62 | 201.25 ± 10.14 | 65.50 ± 9.31 | (50.00 ± 9.40)s | 136.25 ± 3.75 | −65.00 ± 8.20 | (−31.98 ± 2.60)s |
| IL6020 | 5 | 125.80 ± 13.60 | 121.00 ± 4.51 | −4.80 ± 13.54 | (−0.38 ± 9.00)ns | 125.80 ± 9.28 | 4.80 ± 7.64 | (3.87 ± 6.40)ns |
| ILTotal | 76 | 151.16 ± 4.11 | 156.25 ± 4.75 | 5.09 ± 4.81 | (5.60 ± 3.00)ns | 139.11 ± 4.77 | −17.14 ± 4.82 | (−7.77 ± 3.22)s |
Note: Summary of FBG (mg/dl) of male mice of 13 different of CC lines at age 8 weeks (w0 of the beginning of the experiment), at 12 weeks after maintaining on HFD (w12 + SE), changes in FBG (ΔFBG) between weeks 12 and week zero ((ΔFBG) (w0–12 + SE)) and %FBG changes between this period including standard error (% change ± SE) and indicating the significant status (S), FBG after 6 weeks treatment with NDM FBG (wk18 ± SE), differences in %FBG changes (ΔFBG (Wk12–18 + SE)) between weeks 18 and 12, percentage of FBG changes between this period including standard error (% change ± SE) and indicating the significant (S) or non‐significant (NS) status.