Video 6.

GBA1 p.L483P variant and also the LRRK2 Asian variant p.R1628P. Parkinson's disease in this patient was diagnosed at the age of 44 years. She underwent bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) at the age of 57 years. The video, taken at the age of 59 years, was in the stimulation‐ON, medication‐ON (3.5 hr post‐dose) condition. Parkinsonian signs including bradykinesia can be observed, of mild‐to‐moderate severity. She is able to stand up quickly and walk independently without an aid (albeit slowed, with reduced arm swing bilaterally), and is able to recover during pull test. However, she has difficulty following simple verbal/gestural commands, with Montreal Cognitive Assessment (MoCA) score of only 9/30. The patient was later found to have the GBA1 p.L483P (p.L444P) variant (which could be an explanation for her dementia), and also the LRRK2 “Asian variant” p.R1628P. Courtesy: Prof. Shen‐Yang Lim.