Table II.
Regulatory mechanism of circ_NRIP1 in certain cancer types.
| Cancer type | Biological function impacted by circ_NRIP1 | Targeted miRNA | Downstream molecules impacted | Year | (Refs.) |
|---|---|---|---|---|---|
| OC | P ↑ M ↑ I ↑ CR ↑ | miR-211-5p | HOXC8, cyclin D1, MMP2, MMP9 | 2020 | (40) |
| CC | P ↑ M ↑ I ↑ | miR-629-3p | PTP4A1, ERK1, ERK2 | 2020 | (49) |
| CRC | P ↑ M ↑ I ↑ CR↑ | miR-532-3p | - | 2021 | (60) |
| ESCC | P ↑ M ↑ I ↑ A ↑ EMT ↑ | miR-595 | SEMA4D, SNAI1 | 2021 | (63) |
| GC | P ↑ M ↑ I ↑ | miR-149-5p | AKT1 | 2019 | (67) |
| P ↑ M ↑ I ↑ G ↑ | miR-186-5p | MYH9 | 2020 | (70) | |
| P ↑ M ↑ I ↑ G ↑ | miR-138-5p | - | 2020 | (71) | |
| BC | P ↑ M ↑ I ↑ AG ↑ | miR-1253 | DDAH1 | 2021 | (74) |
| P ↑ M ↑ I ↑ EMT ↑ | miR-653 | ZEB2 | 2019 | (77) | |
| NPC | P ↑ M ↑ I ↑ CR ↑ | miR-515-5p | IL-25 | 2021 | (85) |
| PTC | P ↑ M ↑ I ↑ A ↑ | miR-195-5p | JAK2, STAT1, p38 | 2021 | (86) |
| miR-653-5p | PBX3 | 2022 | (90) | ||
| OS | P ↑ M ↑ I ↑ | miR-199a | FOXC2 | 2021 | (111) |
| miR-532-3p | AKT3 | 2021 | (113) |
OC, ovarian cancer; CC, cervical cancer, CRC, colorectal cancer; ESCC, esophageal squamous cell cancer; GC, gastric cancer; BC, breast cancer; NPC, nasopharyngeal carcinoma; PTC, papillary thyroid carcinoma; OS, osteosarcoma; P, proliferative capacity of tumor cells; M, migration capacity of tumor cells; I, invasive capacity of tumor cells; A, apoptosis of tumor cells; CR, chemoresistance; G, glycolysis; AG, Angiogenesis; EMT, epithelial-mesenchymal transition; HOXC8, homeobox C8; MMP2, matrix metalloproteinase 2; MMP9, matrix metalloproteinase 9; PTP4A1, protein tyrosine phosphatase 4A1; ERK1, extracellular regulated protein kinase1; ERK2, extracellular regulated protein kinase2; SEMA4D, semaphoring 4D; SNAI1, snail family transcriptional repressor 1; AKT1, AKT serine/threonine kinase 1; MYH9, myosin heavy chain 9; DDAH1, dimethylarginine dimethylaminohydrolase 1; ZEB2, zinc finger E-box binding homeobox 2; IL-25, interleukin 25; JAK2, Janus kinase 2; STAT1, signal transducer and activator of transcription 1; p38, p38 kinase; PBX3, pre-B-cell leukemia homeobox 3; FOXC2, forkhead box C2; AKT3, AKT serine/threonine kinase 3.