Skip to main content
. 2023 Jun 16;78(Suppl 1):38–43. doi: 10.1093/gerona/glad022

Figure 1.

Figure 1.

(A) Mean 24-hour GH levels. The dashed line indicates 24-hour mean GH level for young men and women combined (~1.3 µg/L). *p < .001 for MK-677 versus placebo. (B) Serum IGF-I levels. The lower dotted line indicates the lower limit of the IGF-I normal range for older adults (59–225 µg/L), and the upper dashed line indicates the lower limit in adults aged 21–25 years (116–358 µg/L). (C) Representative 24-hour GH profile in a 70-year-old man with a body mass index of 23.2 kg/m2 who received MK-677 for 1 year. His 24-hour mean GH levels were 0.37, 1.0, and 0.86 µg/L at baseline, 6 months, and 12 months, respectively. The pulsatile pattern of GH secretion at baseline is maintained and enhanced at 6 and 12 months, primarily because of increased secretion per peak rather than peak frequency. Reproduced with permission from Nass et al. (9). GH = growth hormone; IGF-1 = insulin-like growth factor.