Table 1.

MK-0677 Study in Healthy Older Adults

	Change Versus Baseline at 12 Months
	Placebo (kg)	MK-0677 (kg)
FFM	−0.5 (CI, −1.1 to 0.2)	1.1 (CI, 0.7 to 1.5)***
Total appendicular FFM	−0.3 (CI, −0.6 to 0.1)	0.5 (CI, 0.3 to 0.8)***
Increase total appendicular fat on MK-0677 versus placebo	0.24	1.1**
Body weight	0.8 (CI, −0.3 to 1.8)	2.7 (CI, 2.0 to 3.5)*

Notes: GH 24-h mean GH increased 1.8-fold (CI, 1.56- to 2.0-fold) from baseline (p < .001). IGF-1 Serum IGF-I levels also increased by 1.5-fold (CI, 1.4- to 1.6-fold; p < .001). FFM = fat-free mass; GH = growth hormone; IGF-1 = insulin-like growth factor.

^*** p < .001.

^** p = .001.

*p = .003.