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. 2023 Feb 1;117(4):717–730. doi: 10.1016/j.ajcnut.2023.01.018

FIGURE 2.

FIGURE 2

Variable importance plot (A) and regression parameter profile (B) from PLS analysis (n = 28 for 2 mo; n = 23 for 6 mo). This graph shows the variable important plot (A) and regression parameter profile (B), where in A, several predictors (biomarkers) met or exceeded the Variable Importance for Projection (VIP) statistic Wold of 0.8. The VIP statistic of Wold illustrates the contribution of each predictor in fitting the PLS model for both predictors and clinical outcomes. The most important biomarkers for changes at 6 mo were TNF-α, IL-1RA, and all the SCFAs, whereas changes at 2 mo had similar important biomarkers with the addition of IL-1β. The regression parameter profile shows absolute coefficients for the centered and scaled parameter estimates (B). GAD-7, Generalized Anxiety Disorder 7-Item Scale; IL-1β, interleukin 1 beta; IL-1RA, interleukin 1 receptor agonist; IL-6, interleukin 6; PLS, partial least squares analysis; SCL-20, Depression Symptom Checklist-20.