TABLE 2.

Pearson partial correlation coefficients (r_partial) and P values for changes in biomarkers at 2 mo and changes in clinical outcomes at 2 and 6 mo¹

Biomarker change at 2 mo	SCL-20 Change						GAD-7 Change
	at 2 mo (n = 28)			at 6 mo (n = 23)			at 2 mo (n = 28)			at 6 mo (n = 23)
	rpartial	P	FDR P	rpartial	P	FDR P	rpartial	P	FDR P	rpartial	P	FDR P
CRP	0.10	0.63	0.78	0.16	0.52	0.71	–0.02	0.92	0.95	–0.14	0.55	0.71
IL-1β	–0.31	0.13	0.25	–0.27	0.26	0.39	0.08	0.72	0.86	0.03	0.89	0.94
IL-1RA	–0.40	0.0492	0.143	–0.41	0.07	0.19	–0.19	0.37	0.54	–0.05	0.82	0.90
IL-6	0.13	0.55	0.71	–0.07	0.77	0.87	0.24	0.24	0.38	0.02	0.95	0.95
TNF-α	0.07	0.74	0.86	0.50	0.032	0.123	0.33	0.11	0.24	0.48	0.032	0.123
Propionic acid	0.32	0.11	0.24	0.59	0.012	0.113	0.45	0.022	0.123	0.48	0.032	0.123
Butyric acid	0.31	0.13	0.25	0.68	<0.012	0.043	0.43	0.032	0.123	0.50	0.022	0.123
Isovaleric acid	0.29	0.16	0.27	0.55	0.012	0.123	0.40	0.0462	0.143	0.49	0.032	0.123
Acetic acid	0.24	0.24	0.38	0.45	0.0472	0.143	0.34	0.10	0.23	0.34	0.14	0.25

FDR, false discovery rate; GAD-7, Generalized Anxiety Disorder 7-Item Scale; IL-1β, interleukin 1 beta protein; IL-1RA, interleukin 1 receptor antagonist; IL-6, interleukin 6 protein; P, P value; r_partial, Pearson partial correlation coefficient; SCL-20, Depression Symptom Checklist-20.

¹Partial correlation adjusted for age, sex, and treatment group.

²Indicate P values < 0.05.

³Indicate FDR P values < 0.20.