Figure 4.

Associated risk of death and incident myeloid cancers with CHIP when defined using minimum sequencing allele depth (minAD) thresholds of 3 and 5 in the UKB, assessed using Cox proportional hazards regressions adjusted for age, age-squared, sex, smoking history, and 10 principal components of genetic ancestry. The risk is greater for minAD ≥5, including when hotspot variants (defined as variants observed ≥20 times in the data set) and nonhotspot variants (present <20 times) are assessed separately. The risk increases proportional to the VAF, with nearly a 10-fold increase in risk between VAF <5% and >20% strata.