Table 2.

Treatment-emergent AEs observed in more than 10% of patients and all grade 3 or 4 AEs

AE	Grade 1, n	%	Grade 2, n	%	Grade 3, n	%	Grade 4, n	%	All grade, n	%
Neutropenia	0	0	2	7	1	3	25	83	28	93
Anemia	18	60	8	27	2	7	0	0	28	93
Constipation	21	70	2	7	0	0	0	0	23	77
Nausea	16	53	4	13	0	0	0	0	20	67
ALT elevation	15	50	2	7	2	7	1	3	20	67
Fatigue	12	40	1	3	0	0	0	0	13	43
Rash	10	33	2	7	1	3	0	0	13	43
Peripheral sensory neuropathy	9	30	1	3	0	0	0	0	10	33
AST elevation	8	27	1	3	0	0	1	3	10	33
Dyspepsia	6	20	3	10	0	0	0	0	9	30
Oral pain	8	27	1	3	0	0	0	0	9	30
Headache	7	23	1	3	0	0	0	0	8	27
Insomnia	7	23	1	3	0	0	0	0	8	27
Diarrhea	8	27	0	0	0	0	0	0	8	27
Pain	8	27	0	0	0	0	0	0	8	27
Night sweats	8	27	0	0	0	0	0	0	8	27
Myalgia	7	23	1	3	0	0	0	0	8	27
Vomiting	5	17	2	7	1	3	0	0	8	27
Dyspnea	6	20	1	3	0	0	0	0	7	23
Alopecia	5	17	1	3	0	0	0	0	6	20
Hypokalemia	6	20	0	0	0	0	0	0	6	20
Upper respiratory tract infection	0	0	5	17	1	3	0	0	6	20
Thrombocytopenia	4	13	2	7	0	0	0	0	6	20
Bone pain	4	13	1	3	0	0	0	0	5	17
Back pain	5	17	0	0	0	0	0	0	5	17
Mucositis oral	5	17	0	0	0	0	0	0	5	17
Febrile neutropenia	0	0	0	0	5	17	0	0	5	17
Cough	3	10	1	3	0	0	0	0	4	13
Anxiety	3	10	1	3	0	0	0	0	4	13
Chills	4	13	0	0	0	0	0	0	4	13
Dry mouth	4	13	0	0	0	0	0	0	4	13
Arthralgia	4	13	0	0	0	0	0	0	4	13
Hyponatremia	0	0	0	0	3	10	0	0	3	10
Syncope	0	0	0	0	3	10	0	0	3	10
Sepsis	0	0	0	0	1	3	1	3	2	7
Colonic obstruction	0	0	0	0	0	0	1	3	1	3
Colon abscess	0	0	0	0	0	0	1	3	1	3
Conjunctivitis	0	0	0	0	1	3	0	0	1	3
Total	30	100	23	77	13	43	25	83	30	100