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. 2023 Jun 16;13(27):18223–18228. doi: 10.1039/d3ra02672h

IC50 (μM) values of anti-proliferative effects of compound 1 and 3a.

Samples SMMC-7721 LO2 HaCaT
1 15.8 ± 0.9 >40 >40
3 >40 a 25.4 ± 0.3
Cisplatin 12.3 ± 0.3 2.9 ± 0.2 a
Taxol <0.008 <0.008 a
MTX a a 41.2 ± 0.8
a

“—” means that this compound was not tested in the corresponding experiment.