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Competition assay of select DICER1 variants. (A) Schematic of expected results of competition assay based on whether DICER1 mutants can bind pre-miRNA or not. (B) Auto-radiograph of competition assay with increasing amounts of competing protein. RNase III inactive mutant represent DICER1 bearing the p.D1320A and p.E1813K mutations rendering the protein unable to cleave, but able to bind pre-miR-122.
